Advanced Hepatocellular Carcinoma with Bone Metastases: Prevalence, Associated Factors, and Survival Estimation

Xu Guo, Yao Xu, Xin Wang, Feng Lin, Haixiao Wu, Jincai Duan, Yuqing Xiong, Xiuxin Han, Vladimir P. Baklaushev, Shunbin Xiong, Vladimir P. Chekhonin, Karl Peltzer, Guowen Wang, Chao Zhang

Research output: Contribution to journalArticle

Abstract

BACKGROUND The objective of the present research was to explore the prevalence, risk, and prognostic factors associated with bone metastases (BM) in newly diagnosed hepatocellular carcinoma (HCC) patients. MATERIAL AND METHODS From 36 507 HCC patients who were registered in Surveillance, Epidemiology, and End Results (SEER) database, we enrolled 1263 with BM at the initial diagnosis of HCC from 2010 to 2014. Kaplan-Meier curves and log-rank tests were used to estimate overall survival for different subgroups. Univariate and multivariate logistic and Cox regression analyses were performed to identify risk factors and independent prognostic factors for BM. RESULTS A total of 1567 (4.29%) HCC patients were detected with BM at initial diagnosis. Male sex, unmarried status, higher T stage, lymph node involvement, intrahepatic metastases, and extrahepatic metastases (lung or brain) were positively associated with BM. The median survival of the patients was 3.00 months (95% CI: 2.77-3.24 months). Marital status and primary tumor surgery were independently associated with the better survival. CONCLUSIONS A list of factors associated with BM occurrence and the prognosis of the advanced HCC patients with BM were found. These associated factors may provide a reference for BM screening in HCC and guide prophylactic treatment in clinical settings.

Original languageEnglish (US)
Pages (from-to)1105-1112
Number of pages8
JournalMedical science monitor : international medical journal of experimental and clinical research
Volume25
DOIs
StatePublished - Feb 10 2019

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Hepatocellular Carcinoma
Neoplasm Metastasis
Bone and Bones
Survival
Marital Status
Epidemiology
Logistic Models
Lymph Nodes
Regression Analysis
Databases
Lung
Brain
Research

ASJC Scopus subject areas

  • Medicine(all)

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Advanced Hepatocellular Carcinoma with Bone Metastases : Prevalence, Associated Factors, and Survival Estimation. / Guo, Xu; Xu, Yao; Wang, Xin; Lin, Feng; Wu, Haixiao; Duan, Jincai; Xiong, Yuqing; Han, Xiuxin; Baklaushev, Vladimir P.; Xiong, Shunbin; Chekhonin, Vladimir P.; Peltzer, Karl; Wang, Guowen; Zhang, Chao.

In: Medical science monitor : international medical journal of experimental and clinical research, Vol. 25, 10.02.2019, p. 1105-1112.

Research output: Contribution to journalArticle

Guo, Xu ; Xu, Yao ; Wang, Xin ; Lin, Feng ; Wu, Haixiao ; Duan, Jincai ; Xiong, Yuqing ; Han, Xiuxin ; Baklaushev, Vladimir P. ; Xiong, Shunbin ; Chekhonin, Vladimir P. ; Peltzer, Karl ; Wang, Guowen ; Zhang, Chao. / Advanced Hepatocellular Carcinoma with Bone Metastases : Prevalence, Associated Factors, and Survival Estimation. In: Medical science monitor : international medical journal of experimental and clinical research. 2019 ; Vol. 25. pp. 1105-1112.
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abstract = "BACKGROUND The objective of the present research was to explore the prevalence, risk, and prognostic factors associated with bone metastases (BM) in newly diagnosed hepatocellular carcinoma (HCC) patients. MATERIAL AND METHODS From 36 507 HCC patients who were registered in Surveillance, Epidemiology, and End Results (SEER) database, we enrolled 1263 with BM at the initial diagnosis of HCC from 2010 to 2014. Kaplan-Meier curves and log-rank tests were used to estimate overall survival for different subgroups. Univariate and multivariate logistic and Cox regression analyses were performed to identify risk factors and independent prognostic factors for BM. RESULTS A total of 1567 (4.29{\%}) HCC patients were detected with BM at initial diagnosis. Male sex, unmarried status, higher T stage, lymph node involvement, intrahepatic metastases, and extrahepatic metastases (lung or brain) were positively associated with BM. The median survival of the patients was 3.00 months (95{\%} CI: 2.77-3.24 months). Marital status and primary tumor surgery were independently associated with the better survival. CONCLUSIONS A list of factors associated with BM occurrence and the prognosis of the advanced HCC patients with BM were found. These associated factors may provide a reference for BM screening in HCC and guide prophylactic treatment in clinical settings.",
author = "Xu Guo and Yao Xu and Xin Wang and Feng Lin and Haixiao Wu and Jincai Duan and Yuqing Xiong and Xiuxin Han and Baklaushev, {Vladimir P.} and Shunbin Xiong and Chekhonin, {Vladimir P.} and Karl Peltzer and Guowen Wang and Chao Zhang",
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T1 - Advanced Hepatocellular Carcinoma with Bone Metastases

T2 - Prevalence, Associated Factors, and Survival Estimation

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AU - Xu, Yao

AU - Wang, Xin

AU - Lin, Feng

AU - Wu, Haixiao

AU - Duan, Jincai

AU - Xiong, Yuqing

AU - Han, Xiuxin

AU - Baklaushev, Vladimir P.

AU - Xiong, Shunbin

AU - Chekhonin, Vladimir P.

AU - Peltzer, Karl

AU - Wang, Guowen

AU - Zhang, Chao

PY - 2019/2/10

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N2 - BACKGROUND The objective of the present research was to explore the prevalence, risk, and prognostic factors associated with bone metastases (BM) in newly diagnosed hepatocellular carcinoma (HCC) patients. MATERIAL AND METHODS From 36 507 HCC patients who were registered in Surveillance, Epidemiology, and End Results (SEER) database, we enrolled 1263 with BM at the initial diagnosis of HCC from 2010 to 2014. Kaplan-Meier curves and log-rank tests were used to estimate overall survival for different subgroups. Univariate and multivariate logistic and Cox regression analyses were performed to identify risk factors and independent prognostic factors for BM. RESULTS A total of 1567 (4.29%) HCC patients were detected with BM at initial diagnosis. Male sex, unmarried status, higher T stage, lymph node involvement, intrahepatic metastases, and extrahepatic metastases (lung or brain) were positively associated with BM. The median survival of the patients was 3.00 months (95% CI: 2.77-3.24 months). Marital status and primary tumor surgery were independently associated with the better survival. CONCLUSIONS A list of factors associated with BM occurrence and the prognosis of the advanced HCC patients with BM were found. These associated factors may provide a reference for BM screening in HCC and guide prophylactic treatment in clinical settings.

AB - BACKGROUND The objective of the present research was to explore the prevalence, risk, and prognostic factors associated with bone metastases (BM) in newly diagnosed hepatocellular carcinoma (HCC) patients. MATERIAL AND METHODS From 36 507 HCC patients who were registered in Surveillance, Epidemiology, and End Results (SEER) database, we enrolled 1263 with BM at the initial diagnosis of HCC from 2010 to 2014. Kaplan-Meier curves and log-rank tests were used to estimate overall survival for different subgroups. Univariate and multivariate logistic and Cox regression analyses were performed to identify risk factors and independent prognostic factors for BM. RESULTS A total of 1567 (4.29%) HCC patients were detected with BM at initial diagnosis. Male sex, unmarried status, higher T stage, lymph node involvement, intrahepatic metastases, and extrahepatic metastases (lung or brain) were positively associated with BM. The median survival of the patients was 3.00 months (95% CI: 2.77-3.24 months). Marital status and primary tumor surgery were independently associated with the better survival. CONCLUSIONS A list of factors associated with BM occurrence and the prognosis of the advanced HCC patients with BM were found. These associated factors may provide a reference for BM screening in HCC and guide prophylactic treatment in clinical settings.

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