TY - JOUR
T1 - Advances in the prevention and management of central-line-associated bloodstream infections
T2 - The role of chelator-based catheter locks
AU - Chaftari, Anne Marie
AU - Viola, George M.
AU - Rosenblatt, Joel
AU - Hachem, Ray
AU - Raad, Issam
N1 - Publisher Copyright:
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - The proper functioning of central lines is imperative for the management of patients with cancer or on hemodialysis. However, these lifelines can become infected and can malfunction. Chelators such as citrate and EDTA have been widely studied alone or in combination with other antimicrobial agents in catheter lock solutions to prevent catheter-related bloodstream infections and to maintain catheter patency. Given their anticoagulation, antiplatelet aggregation, antibiofilm, antimicrobial activity, safety profile, as well as their low cost, chelators have long been considered alternatives to heparin and a vital component of catheter lock solutions. In this review, we present a detailed summary of the properties of chelators and in vitro and in vivo studies of chelator-containing lock solutions.
AB - The proper functioning of central lines is imperative for the management of patients with cancer or on hemodialysis. However, these lifelines can become infected and can malfunction. Chelators such as citrate and EDTA have been widely studied alone or in combination with other antimicrobial agents in catheter lock solutions to prevent catheter-related bloodstream infections and to maintain catheter patency. Given their anticoagulation, antiplatelet aggregation, antibiofilm, antimicrobial activity, safety profile, as well as their low cost, chelators have long been considered alternatives to heparin and a vital component of catheter lock solutions. In this review, we present a detailed summary of the properties of chelators and in vitro and in vivo studies of chelator-containing lock solutions.
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U2 - 10.1017/ice.2019.162
DO - 10.1017/ice.2019.162
M3 - Review article
C2 - 31230604
AN - SCOPUS:85067864884
SN - 0899-823X
VL - 40
SP - 1036
EP - 1045
JO - Infection Control and Hospital Epidemiology
JF - Infection Control and Hospital Epidemiology
IS - 9
ER -