Advancing Cancer Research and Medicine with Single-Cell Genomics

Bora Lim, Yiyun Lin, Nicholas Navin

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Single-cell sequencing (SCS) has impacted many areas of cancer research and improved our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and therapeutic resistance. The development and refinement of SCS technologies has led to massive reductions in costs, increased cell throughput, and improved reproducibility, paving the way for clinical applications. However, before translational applications can be realized, there are a number of logistical and technical challenges that must be overcome. This review discusses past cancer research studies, emerging technologies, and future clinical applications that are bound to transform cancer medicine.

Original languageEnglish (US)
Pages (from-to)456-470
Number of pages15
JournalCancer cell
Volume37
Issue number4
DOIs
StatePublished - Apr 13 2020

Keywords

  • cancer evolution
  • intratumor heterogeneity
  • metastasis
  • single cell genomics
  • single cell sequencing
  • therapy resistance
  • translational genomics

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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