TY - JOUR
T1 - Advancing Cancer Research and Medicine with Single-Cell Genomics
AU - Lim, Bora
AU - Lin, Yiyun
AU - Navin, Nicholas
N1 - Funding Information:
This work was supported by grants to N.E.N. from the American Cancer Society ( 129098-RSG-16-092-01-TBG ), the National Cancer Institute ( RO1CA240526 , RO1CA236864 ), the Chan Zuckerberg Initiative ( HCA-A-1704-01668 ), the Emerson Collective Cancer Research Fund ( 144300-80-121457-19 ), and the CPRIT Single Cell Genomics Center ( RP180684 ). N.E.N. and B.L. are supported by the MD Anderson Moonshot Program . B.L. is supported by the SWOG Hope Foundation grant and the Morgan Welch Inflammatory Breast Cancer Program.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/4/13
Y1 - 2020/4/13
N2 - Single-cell sequencing (SCS) has impacted many areas of cancer research and improved our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and therapeutic resistance. The development and refinement of SCS technologies has led to massive reductions in costs, increased cell throughput, and improved reproducibility, paving the way for clinical applications. However, before translational applications can be realized, there are a number of logistical and technical challenges that must be overcome. This review discusses past cancer research studies, emerging technologies, and future clinical applications that are bound to transform cancer medicine.
AB - Single-cell sequencing (SCS) has impacted many areas of cancer research and improved our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and therapeutic resistance. The development and refinement of SCS technologies has led to massive reductions in costs, increased cell throughput, and improved reproducibility, paving the way for clinical applications. However, before translational applications can be realized, there are a number of logistical and technical challenges that must be overcome. This review discusses past cancer research studies, emerging technologies, and future clinical applications that are bound to transform cancer medicine.
KW - cancer evolution
KW - intratumor heterogeneity
KW - metastasis
KW - single cell genomics
KW - single cell sequencing
KW - therapy resistance
KW - translational genomics
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U2 - 10.1016/j.ccell.2020.03.008
DO - 10.1016/j.ccell.2020.03.008
M3 - Review article
C2 - 32289270
AN - SCOPUS:85082763717
SN - 1535-6108
VL - 37
SP - 456
EP - 470
JO - Cancer cell
JF - Cancer cell
IS - 4
ER -