Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment

Victoria C. Yan; Florian L. Muller

doi:10.1021/acsmedchemlett.0c00316

Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment

Victoria C. Yan, Florian L. Muller

Cancer Systems Imaging

Research output: Contribution to journal › Review article › peer-review

117 Scopus citations

Abstract

While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant metabolite reaching the lungs. With its synthetic simplicity and in vivo efficacy in the veterinary setting, we contend that GS-441524 is superior to remdesivir for Covid-19 treatment.

Original language	English (US)
Pages (from-to)	1361-1366
Number of pages	6
Journal	ACS Medicinal Chemistry Letters
Volume	11
Issue number	7
DOIs	https://doi.org/10.1021/acsmedchemlett.0c00316
State	Published - Jul 9 2020

Keywords

Covid-19
Prodrug
drug delivery
metabolism
remdesivir

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1021/acsmedchemlett.0c00316

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abstract = "While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant metabolite reaching the lungs. With its synthetic simplicity and in vivo efficacy in the veterinary setting, we contend that GS-441524 is superior to remdesivir for Covid-19 treatment.",

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Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment

Abstract

Keywords

ASJC Scopus subject areas

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