TY - JOUR
T1 - Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors
T2 - A randomized controlled trial
AU - Dieli-Conwright, Christina M.
AU - Courneya, Kerry S.
AU - Demark-Wahnefried, Wendy
AU - Sami, Nathalie
AU - Lee, Kyuwan
AU - Sweeney, Frank C.
AU - Stewart, Christina
AU - Buchanan, Thomas A.
AU - Spicer, Darcy
AU - Tripathy, Debu
AU - Bernstein, Leslie
AU - Mortimer, Joanne E.
N1 - Funding Information:
This work was supported by grants K07CA160718 from the National Cancer Institute, UL1TR001855 and UL1TR000130 from the National Center for Advancing Translational Science (NCATS) of the U.S. National Institutes of Health.
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/10/19
Y1 - 2018/10/19
N2 - Background: Exercise is an effective strategy to improve quality of life and physical fitness in breast cancer survivors; however, few studies have focused on the early survivorship period, minorities, physically inactive and obese women, or tested a combined exercise program and measured bone health. Here, we report the effects of a 16-week aerobic and resistance exercise intervention on patient-reported outcomes, physical fitness, and bone health in ethnically diverse, physically inactive, overweight or obese breast cancer survivors. Methods: One hundred breast cancer survivors within 6 months of completing adjuvant treatment were assessed at baseline, post-intervention, and 3-month follow-up (exercise group only) for physical fitness, bone mineral density, serum concentrations of bone biomarkers, and quality of life. The exercise intervention consisted of moderate-vigorous (65-85% heart rate maximum) aerobic and resistance exercise thrice weekly for 16 weeks. Differences in mean changes for outcomes were evaluated using mixed-model repeated measure analysis. Results: At post-intervention, the exercise group was superior to usual care for quality of life (between group difference: 14.7, 95% CI: 18.2, 9.7; p < 0.001), fatigue (p < 0.001), depression (p < 0.001), estimated VO2max (p < 0.001), muscular strength (p < 0.001), osteocalcin (p = 0.01), and BSAP (p = 0.001). At 3-month follow-up, all patient-reported outcomes and physical fitness variables remained significantly improved compared to baseline in the exercise group (p < 0.01). Conclusions: A 16-week combined aerobic and resistance exercise program designed to address metabolic syndrome in ethnically-diverse overweight or obese breast cancer survivors also significantly improved quality of life and physical fitness. Our findings further support the inclusion of supervised clinical exercise programs into breast cancer treatment and care. Trial registration: This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010.
AB - Background: Exercise is an effective strategy to improve quality of life and physical fitness in breast cancer survivors; however, few studies have focused on the early survivorship period, minorities, physically inactive and obese women, or tested a combined exercise program and measured bone health. Here, we report the effects of a 16-week aerobic and resistance exercise intervention on patient-reported outcomes, physical fitness, and bone health in ethnically diverse, physically inactive, overweight or obese breast cancer survivors. Methods: One hundred breast cancer survivors within 6 months of completing adjuvant treatment were assessed at baseline, post-intervention, and 3-month follow-up (exercise group only) for physical fitness, bone mineral density, serum concentrations of bone biomarkers, and quality of life. The exercise intervention consisted of moderate-vigorous (65-85% heart rate maximum) aerobic and resistance exercise thrice weekly for 16 weeks. Differences in mean changes for outcomes were evaluated using mixed-model repeated measure analysis. Results: At post-intervention, the exercise group was superior to usual care for quality of life (between group difference: 14.7, 95% CI: 18.2, 9.7; p < 0.001), fatigue (p < 0.001), depression (p < 0.001), estimated VO2max (p < 0.001), muscular strength (p < 0.001), osteocalcin (p = 0.01), and BSAP (p = 0.001). At 3-month follow-up, all patient-reported outcomes and physical fitness variables remained significantly improved compared to baseline in the exercise group (p < 0.01). Conclusions: A 16-week combined aerobic and resistance exercise program designed to address metabolic syndrome in ethnically-diverse overweight or obese breast cancer survivors also significantly improved quality of life and physical fitness. Our findings further support the inclusion of supervised clinical exercise programs into breast cancer treatment and care. Trial registration: This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010.
KW - Exercise
KW - bone health
KW - breast cancer
KW - physical fitness
KW - quality of life
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U2 - 10.1186/s13058-018-1051-6
DO - 10.1186/s13058-018-1051-6
M3 - Article
C2 - 30340503
AN - SCOPUS:85055079794
SN - 1465-5411
VL - 20
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 1
M1 - 124
ER -