Aetiology of jaagsiekte: experimental transmission to lambs by means of cultured cells and cell homogenates.

D. W. Verwoerd, Ethel-Michele de Villiers, R. C. Tustin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Studies on the transmission of jaagsiekte (ovine pulmonary adenomatosis) both by subinoculation of cells of known sex and by cell homogenates into male and female lambs are reported. The results obtained indicate a thymocyte-dependent rejection of male cells in female recipients in contrast to the successful transplantation of male cells in male animals and female cells in both sexes. This suggests the presence of a surface antigen determined by the gamma-chromosome in the tumour cells. A second mechanism of transmission, dependent on the transformation of the recipient's cells, was demonstrated by 2 cases of heterologous transplantation and confirmed by inoculation of cellular homogenates.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalOnderstepoort Journal of Veterinary Research
Volume47
Issue number1
StatePublished - Mar 1980

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Ovine Pulmonary Adenomatosis
ovine pulmonary adenomatosis
cultured cells
etiology
Cultured Cells
lambs
germ cells
cells
xenotransplantation
thymocytes
surface antigens
Heterologous Transplantation
Cell Transplantation
Thymocytes
Surface Antigens
chromosomes
Chromosomes

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Aetiology of jaagsiekte : experimental transmission to lambs by means of cultured cells and cell homogenates. / Verwoerd, D. W.; de Villiers, Ethel-Michele; Tustin, R. C.

In: Onderstepoort Journal of Veterinary Research, Vol. 47, No. 1, 03.1980, p. 13-18.

Research output: Contribution to journalArticle

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