Age-dependent macrophage functions in New Zealand Black mice

Menashe Bar-Eli, Ruth Gallily

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Various functions of macrophage derived from young (2-month-old) and old (14- to 17-month-old) New Zealand Black (NZB) mice with autoimmune disease were studied and compared with macrophage functions of age-matched BALB/c mice. Macrophages from young and old NZB mice demonstrated elevated levels of β-glucuronidase, cathepsin D, lysozyme, and DNase compared with those from age-matched BALB/c. DNase activity in the macrophages of NZB mice significantly increased with age. Macrophages from young and old NZB mice had greater phagocytic capacity for both 125I-labeled Shigella flexneri and Staphylococcus albus than did BALB/c macrophages. NZB macrophages from both young and old mice had higher bactericidal activity against S. albus than those from age-matched BALB/c mice. The number of macrophage/granulocyte colony-forming cells (CFC) in both bone marrow and spleen was markedly higher in young and old NZB mice than in BALB/c mice. Colony-stimulating factor (CSF) released by macrophages derived from NZB mice had higher CFC activity than that released from macrophages of age-matched BALB/c mice. In NZB mice, the CSF activity significantly increased with age. It is suggested that potentiation of macrophage number and activity compensates for the deficiency of T cell functions in NZB mice with autoimmune disease.

Original languageEnglish (US)
Pages (from-to)309-317
Number of pages9
JournalCellular Immunology
Volume45
Issue number2
DOIs
StatePublished - Jul 1979

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New Zealand
Macrophages
Deoxyribonucleases
Autoimmune Diseases
Shigella flexneri
Colony-Stimulating Factors
Cathepsin D
Macrophage Colony-Stimulating Factor
Glucuronidase
Muramidase
Staphylococcus
Granulocytes
Spleen
Bone Marrow
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Age-dependent macrophage functions in New Zealand Black mice. / Bar-Eli, Menashe; Gallily, Ruth.

In: Cellular Immunology, Vol. 45, No. 2, 07.1979, p. 309-317.

Research output: Contribution to journalArticle

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