Age-specific health-related quality of life in long-term and very long-term colorectal cancer survivors versus population controls–a population-based study *

Melissa S.Y. Thong, Lena Koch-Gallenkamp, Lina Jansen, Heike Bertram, Andrea Eberle, Bernd Holleczek, Mechthild Waldeyer-Sauerland, Annika Waldmann, Sylke Ruth Zeissig, Hermann Brenner, Volker Arndt

Research output: Contribution to journalArticle

Abstract

Background: Previous research suggests an age differential in health-related quality of life (HRQOL) among long-term (5–10 years post-diagnosis, LTS) colorectal cancer (CRC) survivors. Few studies have specifically addressed the association of age differentials with HRQOL for very long-term CRC survivors (>10 years post-diagnosis, VLTS) and non-cancer population controls. We aimed to assess possible deficits in HRQOL of disease-free CRC-LTS and CRC-VLTS in comparison with non-cancer population controls, and whether the observed pattern varies by age and time since diagnosis. Methods: We used data from the CAncEr Survivorship - A multi-Regional (CAESAR+) study in collaboration with five population-based German cancer registries. HRQOL from controls was accessed from the Lebensqualität in DEeutschland (LinDE) study. All respondents completed the European Organization for Research and Treatment of Cancer Quality of Life Core-30 questionnaire. We calculated least square means of HRQOL scores. Analyses were adjusted for age, sex, and education, where appropriate. Results: The sample included 862 CRC-LTS, 400 CRC-VLTS and 1689 controls. CRC survivors reported overall good HRQOL but significantly poorer social functioning and more problems with dyspnea, constipation, diarrhea and finances than controls. When stratified by age, deficits in functioning and global health, and more problems with symptoms and finances were noted mainly among younger CRC survivors. Further stratification by time since diagnosis showed that similar deficits in HRQOL and symptoms were noted mainly among the younger CRC-LTS group when compared with controls. Generally, CRC-VLTS reported comparable HRQOL to controls. An exception was noted for diarrhea, whereby CRC survivors, regardless of age and time since diagnosis, reported significantly more problems with this symptom than controls. Conclusions: In comparison with non-cancer controls, disease-free CRC survivors reported overall good HRQOL but experience persistent specific detriments in HRQOL many years after diagnosis. In age stratified analyses, HRQOL deficits were noted mainly among younger CRC-LTS.

Original languageEnglish (US)
JournalActa Oncologica
DOIs
StatePublished - Jan 1 2019

Fingerprint

Survivors
Colorectal Neoplasms
Quality of Life
Population
Population Control
Diarrhea
Neoplasms
Sex Education
Life Change Events
Constipation
Least-Squares Analysis
Research
Quality Control
Dyspnea
Registries
Survival Rate
Organizations

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Age-specific health-related quality of life in long-term and very long-term colorectal cancer survivors versus population controls–a population-based study * . / Thong, Melissa S.Y.; Koch-Gallenkamp, Lena; Jansen, Lina; Bertram, Heike; Eberle, Andrea; Holleczek, Bernd; Waldeyer-Sauerland, Mechthild; Waldmann, Annika; Zeissig, Sylke Ruth; Brenner, Hermann; Arndt, Volker.

In: Acta Oncologica, 01.01.2019.

Research output: Contribution to journalArticle

Thong, Melissa S.Y. ; Koch-Gallenkamp, Lena ; Jansen, Lina ; Bertram, Heike ; Eberle, Andrea ; Holleczek, Bernd ; Waldeyer-Sauerland, Mechthild ; Waldmann, Annika ; Zeissig, Sylke Ruth ; Brenner, Hermann ; Arndt, Volker. / Age-specific health-related quality of life in long-term and very long-term colorectal cancer survivors versus population controls–a population-based study * In: Acta Oncologica. 2019.
@article{f76e2571688842fc9425007b96b9e8fe,
title = "Age-specific health-related quality of life in long-term and very long-term colorectal cancer survivors versus population controls–a population-based study *",
abstract = "Background: Previous research suggests an age differential in health-related quality of life (HRQOL) among long-term (5–10 years post-diagnosis, LTS) colorectal cancer (CRC) survivors. Few studies have specifically addressed the association of age differentials with HRQOL for very long-term CRC survivors (>10 years post-diagnosis, VLTS) and non-cancer population controls. We aimed to assess possible deficits in HRQOL of disease-free CRC-LTS and CRC-VLTS in comparison with non-cancer population controls, and whether the observed pattern varies by age and time since diagnosis. Methods: We used data from the CAncEr Survivorship - A multi-Regional (CAESAR+) study in collaboration with five population-based German cancer registries. HRQOL from controls was accessed from the Lebensqualit{\"a}t in DEeutschland (LinDE) study. All respondents completed the European Organization for Research and Treatment of Cancer Quality of Life Core-30 questionnaire. We calculated least square means of HRQOL scores. Analyses were adjusted for age, sex, and education, where appropriate. Results: The sample included 862 CRC-LTS, 400 CRC-VLTS and 1689 controls. CRC survivors reported overall good HRQOL but significantly poorer social functioning and more problems with dyspnea, constipation, diarrhea and finances than controls. When stratified by age, deficits in functioning and global health, and more problems with symptoms and finances were noted mainly among younger CRC survivors. Further stratification by time since diagnosis showed that similar deficits in HRQOL and symptoms were noted mainly among the younger CRC-LTS group when compared with controls. Generally, CRC-VLTS reported comparable HRQOL to controls. An exception was noted for diarrhea, whereby CRC survivors, regardless of age and time since diagnosis, reported significantly more problems with this symptom than controls. Conclusions: In comparison with non-cancer controls, disease-free CRC survivors reported overall good HRQOL but experience persistent specific detriments in HRQOL many years after diagnosis. In age stratified analyses, HRQOL deficits were noted mainly among younger CRC-LTS.",
author = "Thong, {Melissa S.Y.} and Lena Koch-Gallenkamp and Lina Jansen and Heike Bertram and Andrea Eberle and Bernd Holleczek and Mechthild Waldeyer-Sauerland and Annika Waldmann and Zeissig, {Sylke Ruth} and Hermann Brenner and Volker Arndt",
year = "2019",
month = "1",
day = "1",
doi = "10.1080/0284186X.2018.1557340",
language = "English (US)",
journal = "Acta Oncologica",
issn = "0284-186X",
publisher = "Informa Healthcare",

}

TY - JOUR

T1 - Age-specific health-related quality of life in long-term and very long-term colorectal cancer survivors versus population controls–a population-based study *

AU - Thong, Melissa S.Y.

AU - Koch-Gallenkamp, Lena

AU - Jansen, Lina

AU - Bertram, Heike

AU - Eberle, Andrea

AU - Holleczek, Bernd

AU - Waldeyer-Sauerland, Mechthild

AU - Waldmann, Annika

AU - Zeissig, Sylke Ruth

AU - Brenner, Hermann

AU - Arndt, Volker

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Previous research suggests an age differential in health-related quality of life (HRQOL) among long-term (5–10 years post-diagnosis, LTS) colorectal cancer (CRC) survivors. Few studies have specifically addressed the association of age differentials with HRQOL for very long-term CRC survivors (>10 years post-diagnosis, VLTS) and non-cancer population controls. We aimed to assess possible deficits in HRQOL of disease-free CRC-LTS and CRC-VLTS in comparison with non-cancer population controls, and whether the observed pattern varies by age and time since diagnosis. Methods: We used data from the CAncEr Survivorship - A multi-Regional (CAESAR+) study in collaboration with five population-based German cancer registries. HRQOL from controls was accessed from the Lebensqualität in DEeutschland (LinDE) study. All respondents completed the European Organization for Research and Treatment of Cancer Quality of Life Core-30 questionnaire. We calculated least square means of HRQOL scores. Analyses were adjusted for age, sex, and education, where appropriate. Results: The sample included 862 CRC-LTS, 400 CRC-VLTS and 1689 controls. CRC survivors reported overall good HRQOL but significantly poorer social functioning and more problems with dyspnea, constipation, diarrhea and finances than controls. When stratified by age, deficits in functioning and global health, and more problems with symptoms and finances were noted mainly among younger CRC survivors. Further stratification by time since diagnosis showed that similar deficits in HRQOL and symptoms were noted mainly among the younger CRC-LTS group when compared with controls. Generally, CRC-VLTS reported comparable HRQOL to controls. An exception was noted for diarrhea, whereby CRC survivors, regardless of age and time since diagnosis, reported significantly more problems with this symptom than controls. Conclusions: In comparison with non-cancer controls, disease-free CRC survivors reported overall good HRQOL but experience persistent specific detriments in HRQOL many years after diagnosis. In age stratified analyses, HRQOL deficits were noted mainly among younger CRC-LTS.

AB - Background: Previous research suggests an age differential in health-related quality of life (HRQOL) among long-term (5–10 years post-diagnosis, LTS) colorectal cancer (CRC) survivors. Few studies have specifically addressed the association of age differentials with HRQOL for very long-term CRC survivors (>10 years post-diagnosis, VLTS) and non-cancer population controls. We aimed to assess possible deficits in HRQOL of disease-free CRC-LTS and CRC-VLTS in comparison with non-cancer population controls, and whether the observed pattern varies by age and time since diagnosis. Methods: We used data from the CAncEr Survivorship - A multi-Regional (CAESAR+) study in collaboration with five population-based German cancer registries. HRQOL from controls was accessed from the Lebensqualität in DEeutschland (LinDE) study. All respondents completed the European Organization for Research and Treatment of Cancer Quality of Life Core-30 questionnaire. We calculated least square means of HRQOL scores. Analyses were adjusted for age, sex, and education, where appropriate. Results: The sample included 862 CRC-LTS, 400 CRC-VLTS and 1689 controls. CRC survivors reported overall good HRQOL but significantly poorer social functioning and more problems with dyspnea, constipation, diarrhea and finances than controls. When stratified by age, deficits in functioning and global health, and more problems with symptoms and finances were noted mainly among younger CRC survivors. Further stratification by time since diagnosis showed that similar deficits in HRQOL and symptoms were noted mainly among the younger CRC-LTS group when compared with controls. Generally, CRC-VLTS reported comparable HRQOL to controls. An exception was noted for diarrhea, whereby CRC survivors, regardless of age and time since diagnosis, reported significantly more problems with this symptom than controls. Conclusions: In comparison with non-cancer controls, disease-free CRC survivors reported overall good HRQOL but experience persistent specific detriments in HRQOL many years after diagnosis. In age stratified analyses, HRQOL deficits were noted mainly among younger CRC-LTS.

UR - http://www.scopus.com/inward/record.url?scp=85061229997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061229997&partnerID=8YFLogxK

U2 - 10.1080/0284186X.2018.1557340

DO - 10.1080/0284186X.2018.1557340

M3 - Article

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

ER -