Allogeneic stem cell transplantation using HLA-matched donors for acute myeloid leukemia with deletion 5q or monosomy 5: A study from the Acute Leukemia Working Party of the EBMT

Xavier Poiré, Myriam Labopin, Emmanuelle Polge, Edouard Forcade, Arnold Ganser, Liisa Volin, Mauricette Michallet, Didier Blaise, Ibrahim Yakoub-Agha, Johan Maertens, Carlos Richard Espiga, Jan Cornelissen, Jürgen Finke, Mohamad Mohty, Jordi Esteve, Arnon Nagler

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Abstract

Deletion 5q or monosomy 5 (-5/5q-) in acute myeloid leukemia (AML) is a common high-risk feature that is referred to allogeneic stem cell transplantation. However, -5/5q- is frequently associated with other high-risk cytogenetic aberrations such as complex karyotype, monosomal karyotype, monosomy 7 (-7), or 17p abnormalities (abn (17p)), the significance of which is unknown. In order to address this question, we studied adult patients with AML harboring -5/5q- having their first allogeneic transplantation between 2000 and 2015. Five hundred and one patients with -5/5q- have been analyzed. Three hundred and thirty-eight patients (67%) were in first remission and 142 (28%) had an active disease at time of allogeneic transplantation. The 2-year probabilities of overall survival and leukemia-free survival were 27% and 20%, respectively. The 2- year probability of treatment-related mortality was 20%. We identified four different cytogenetic groups according to additional abnormalities with prognostic impact: -5/5q- without complex karyotype, monosomal karyotype or abn(17p), -5/5q- within a complex karyotype, -5/5q- within a monosomal karyotype and the combination of -5/5q- with abn(17p). In multivariate analysis, factors associated with worse overall survival and leukemia-free survival across the four groups were active disease, age, monosomal karyotype, and abn(17p). The presence of -5/5q- without monosomal karyotype or abn(17p) was associated with a significantly better survival rate while -5/5q- in conjunction with monosomal karyotype or abn(17p) translated into a worse outcome. The patients harboring the combination of -5/5q- with abn(17p) showed very limited benefit from allogeneic transplantation.

Original languageEnglish (US)
Pages (from-to)414-423
Number of pages10
JournalHaematologica
Volume105
Issue number2
DOIs
StatePublished - Jan 31 2020

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ASJC Scopus subject areas

  • Hematology

Cite this

Poiré, X., Labopin, M., Polge, E., Forcade, E., Ganser, A., Volin, L., Michallet, M., Blaise, D., Yakoub-Agha, I., Maertens, J., Espiga, C. R., Cornelissen, J., Finke, J., Mohty, M., Esteve, J., & Nagler, A. (2020). Allogeneic stem cell transplantation using HLA-matched donors for acute myeloid leukemia with deletion 5q or monosomy 5: A study from the Acute Leukemia Working Party of the EBMT. Haematologica, 105(2), 414-423. https://doi.org/10.3324/haematol.2019.216168