Alpinia oxyphylla Miq extract ameliorates cardiac fibrosis associated with D-galactose induced aging in rats

Yung Ming Chang, Shanmugam Tamilselvi, Hung Jen Lin, Chin Chuan Tsai, Yueh Min Lin, Cecilia Hsuan Day, Vijaya Padma Viswanadha, Hsin Nung Chang, Wei Wen Kuo, Chih-Yang Huang

Research output: Contribution to journalArticle

Abstract

Cardiac fibrosis is a common pathophysiological process observed during chronic and stress-induced acceleration of cardiac aging. Fibrosis is a necessary process during wound healing and tissue repair. However, its deposition in organs would proceed to scarring and organ damage. Here Alpinate Oxyphyllae Fructus (AOF), a Chinese medicine extract was used to protect aging heart from collagen accumulation. About 8 weeks old, male SD rats were randomly divided into (i) Control, (ii) D-galactose induced aging (IA), (iii) IA + AOF 50 (AOF low, AL), (iv) IA + AOF 100 (AOF medium, AM), (v) IA + AOF 150 (AOF high, AH) mg/kg/day, AOF was administered orally. After 8 weeks rats were sacrificed and hearts were collected. Results showed collagen deposition and up-regulation of matrix metalloproteinases-MMP-2 and -9 in D-galactose-induced aging rats. Furthermore, western blotting and immunostaining were also confirmed the upregulation of TGF-β1 mediated fibrosis in aging induced rats. However, collagen deposition and fibrosis were significantly decreased by AOF treatments (AM and AH). AOF treatments salvaged the cardiac fibrosis. Hence, AOF might be a potential therapeutic agent in the prevention of cardiac fibrosis associated with aging. The protective effects of AOF might have promising results in anti-aging treatments.

Original languageEnglish (US)
Pages (from-to)172-178
Number of pages7
JournalEnvironmental Toxicology
Volume34
Issue number2
DOIs
StatePublished - Feb 1 2019

Fingerprint

Alpinia
Galactose
Rats
Fibrosis
Aging of materials
Collagen
collagen
Up-Regulation
Matrix Metalloproteinases
Matrix Metalloproteinase 2
Wound Healing
Cicatrix
Western Blotting
Medicine
medicine
repair
Repair

Keywords

  • AOF
  • D-galactose
  • aging
  • cardiac fibrosis

ASJC Scopus subject areas

  • Toxicology
  • Management, Monitoring, Policy and Law
  • Health, Toxicology and Mutagenesis

Cite this

Alpinia oxyphylla Miq extract ameliorates cardiac fibrosis associated with D-galactose induced aging in rats. / Chang, Yung Ming; Tamilselvi, Shanmugam; Lin, Hung Jen; Tsai, Chin Chuan; Lin, Yueh Min; Day, Cecilia Hsuan; Viswanadha, Vijaya Padma; Chang, Hsin Nung; Kuo, Wei Wen; Huang, Chih-Yang.

In: Environmental Toxicology, Vol. 34, No. 2, 01.02.2019, p. 172-178.

Research output: Contribution to journalArticle

Chang, YM, Tamilselvi, S, Lin, HJ, Tsai, CC, Lin, YM, Day, CH, Viswanadha, VP, Chang, HN, Kuo, WW & Huang, C-Y 2019, 'Alpinia oxyphylla Miq extract ameliorates cardiac fibrosis associated with D-galactose induced aging in rats' Environmental Toxicology, vol. 34, no. 2, pp. 172-178. https://doi.org/10.1002/tox.22671
Chang, Yung Ming ; Tamilselvi, Shanmugam ; Lin, Hung Jen ; Tsai, Chin Chuan ; Lin, Yueh Min ; Day, Cecilia Hsuan ; Viswanadha, Vijaya Padma ; Chang, Hsin Nung ; Kuo, Wei Wen ; Huang, Chih-Yang. / Alpinia oxyphylla Miq extract ameliorates cardiac fibrosis associated with D-galactose induced aging in rats. In: Environmental Toxicology. 2019 ; Vol. 34, No. 2. pp. 172-178.
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