TY - JOUR
T1 - Alterations in interhemispheric functional and anatomical connectivity are associated with tobacco smoking in humans
AU - Viswanath, Humsini
AU - Velasquez, Kenia M.
AU - Thompson-Lake, Daisy Gemma Yan
AU - Savjani, Ricky
AU - Carter, Asasia Q.
AU - Eagleman, David
AU - Baldwin, Philip R.
AU - De La Garza, Richard
AU - Salas, Ramiro
N1 - Publisher Copyright:
© 2015 Viswanath, Velasquez, Thompson-Lake, Savjani, Carter, Eagleman, Baldwin, De La Garza, II and Salas.
PY - 2015/3/9
Y1 - 2015/3/9
N2 - Abnormal interhemispheric functional connectivity correlates with several neurologic and psychiatric conditions, including depression, obsessive-compulsive disorder, schizophrenia, and stroke. Abnormal interhemispheric functional connectivity also correlates with abuse of cannabis and cocaine. In the current report, we evaluated whether tobacco abuse (i.e., cigarette smoking) is associated with altered interhemispheric connectivity. To that end, we examined resting state functional connectivity (RSFC) using magnetic resonance imaging (MRI) in short term tobacco deprived and smoking as usual tobacco smokers, and in non-smoker controls. Additionally, we compared diffusion tensor imaging (DTI) in the same subjects to study differences in white matter. The data reveal a significant increase in interhemispheric functional connectivity in sated tobacco smokers when compared to controls. This difference was larger in frontal regions, and was positively correlated with the average number of cigarettes smoked per day. In addition, we found a negative correlation between the number of DTI streamlines in the genual corpus callosum and the number of cigarettes smoked per day. Taken together, our results implicate changes in interhemispheric functional and anatomical connectivity in current cigarette smokers.
AB - Abnormal interhemispheric functional connectivity correlates with several neurologic and psychiatric conditions, including depression, obsessive-compulsive disorder, schizophrenia, and stroke. Abnormal interhemispheric functional connectivity also correlates with abuse of cannabis and cocaine. In the current report, we evaluated whether tobacco abuse (i.e., cigarette smoking) is associated with altered interhemispheric connectivity. To that end, we examined resting state functional connectivity (RSFC) using magnetic resonance imaging (MRI) in short term tobacco deprived and smoking as usual tobacco smokers, and in non-smoker controls. Additionally, we compared diffusion tensor imaging (DTI) in the same subjects to study differences in white matter. The data reveal a significant increase in interhemispheric functional connectivity in sated tobacco smokers when compared to controls. This difference was larger in frontal regions, and was positively correlated with the average number of cigarettes smoked per day. In addition, we found a negative correlation between the number of DTI streamlines in the genual corpus callosum and the number of cigarettes smoked per day. Taken together, our results implicate changes in interhemispheric functional and anatomical connectivity in current cigarette smokers.
KW - Corpus callosum
KW - Diffusion tensor imaging
KW - Interhemispheric connectivity
KW - Resting state functional connectivity
KW - Tobacco smoking
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U2 - 10.3389/fnhum.2015.00116
DO - 10.3389/fnhum.2015.00116
M3 - Article
C2 - 25805986
AN - SCOPUS:84933677708
SN - 1662-5161
VL - 9
JO - Frontiers in Human Neuroscience
JF - Frontiers in Human Neuroscience
IS - MAR
M1 - 116
ER -