Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer's disease

Arnold M. Salazar, Amanda M. Leisgang, Andrew A. Ortiz, Andrew S. Murtishaw, Jefferson W. Kinney

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive decline of memory and cognitive function. The disease is characterized by the presence of amyloid plaques, tau tangles, altered inflammatory signaling, and alterations in numerous neurotransmitter signaling systems, including γ-aminobutyric acid (GABA). Given the extensive role of GABA in regulating neuronal activity, a careful investigation of GABA-related changes is needed. Further, given persistent inflammation has been demonstrated to drive AD pathology, the presence of GABA B receptor expressed on glia that serve a role regulation of the immune response adds to potential implications of altered GABA in AD. There has not previously been a systematic evaluation of GABA-related changes in an amyloid model of AD that specifically focuses on examining changes in GABA B receptors. In the present study, we examined alterations in several GABA-specific targets in the APP/PS1 mouse model at different ages. In the 4-month-old cohort, no significant deficits in spatial learning and memory or alterations in any of the GABAergic targets were observed compared with wild-type controls. However, we identified significant alterations in several GABA-related targets in the 6-month-old cohort that exhibited spatial learning deficits that include changes in glutamic acid decarboxylase 65, GABA transporter type 3, and GABA B receptors protein and mRNA levels. This was the same cohort at which learning and memory deficits and significant amyloid pathology was observed. Overall, our study provides evidence of altered GABAergic signaling in an amyloid model of AD at a time point consistent with AD-related deficits.

Original languageEnglish (US)
Pages (from-to)129-143
Number of pages15
JournalNeurobiology of Aging
Volume97
DOIs
StatePublished - Jan 2021
Externally publishedYes

Keywords

  • APP/PS1
  • Alzheimer's disease
  • Amyloid-beta
  • GABA
  • GABA B receptors
  • Microglia

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology

Fingerprint

Dive into the research topics of 'Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer's disease'. Together they form a unique fingerprint.

Cite this