Altered cytokine and chemokine profiles in multiple myeloma and its precursor disease

Adriana Zingone; Weixin Wang; Meghan Corrigan-Cummins; S. Peter Wu; Ryan Plyler; Neha Korde; Mary Kwok; Elisabet E. Manasanch; Nishant Tageja; Manisha Bhutani; Marcia Mulquin; Diamond Zuchlinski; Mary Ann Yancey; Mark Roschewski; Yong Zhang; Aldo M. Roccaro; Irene M. Ghobrial; Katherine R. Calvo; Ola Landgren

doi:10.1016/j.cyto.2014.05.017

Altered cytokine and chemokine profiles in multiple myeloma and its precursor disease

Adriana Zingone, Weixin Wang, Meghan Corrigan-Cummins, S. Peter Wu, Ryan Plyler, Neha Korde, Mary Kwok, Elisabet E. Manasanch, Nishant Tageja, Manisha Bhutani, Marcia Mulquin, Diamond Zuchlinski, Mary Ann Yancey, Mark Roschewski, Yong Zhang, Aldo M. Roccaro, Irene M. Ghobrial, Katherine R. Calvo, Ola Landgren

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Currently, no reliable biomarkers are available to predict transformation from smoldering myeloma (SMM) to multiple myeloma (MM). Using an ultrasensitive enzyme-linked immunosorbent assay (ELISA) we assessed the levels of a broad range of cytokines and chemokines in the peripheral blood (PB) and bone marrow (BM) supernatant collected from 14 SMM and 38 MM patients and compared to healthy donors. We found significantly increased levels of key cytokines, in particular CXCL8 (IL-8), associated with progressive disease state (controls → SMM → MM). Cytokine profiles were found similar in PB and BM. Five of fourteen SMM patients (36%) progressed to MM.Our findings, although based on a limited number of patients, suggest that serum-based cytokines may have a future role as biomarkers for disease progression and could potentially be assessed as novel targets for treatment.

Original language	English (US)
Pages (from-to)	294-297
Number of pages	4
Journal	Cytokine
Volume	69
Issue number	2
DOIs	https://doi.org/10.1016/j.cyto.2014.05.017
State	Published - Oct 1 2014
Externally published	Yes

Keywords

CXCL8
Chemokines
Multiple myeloma

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Hematology
Molecular Biology

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10.1016/j.cyto.2014.05.017

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Zingone, A., Wang, W., Corrigan-Cummins, M., Wu, S. P., Plyler, R., Korde, N., Kwok, M., Manasanch, E. E., Tageja, N., Bhutani, M., Mulquin, M., Zuchlinski, D., Yancey, M. A., Roschewski, M., Zhang, Y., Roccaro, A. M., Ghobrial, I. M., Calvo, K. R., & Landgren, O. (2014). Altered cytokine and chemokine profiles in multiple myeloma and its precursor disease. Cytokine, 69(2), 294-297. https://doi.org/10.1016/j.cyto.2014.05.017

Zingone, A, Wang, W, Corrigan-Cummins, M, Wu, SP, Plyler, R, Korde, N, Kwok, M, Manasanch, EE, Tageja, N, Bhutani, M, Mulquin, M, Zuchlinski, D, Yancey, MA, Roschewski, M, Zhang, Y, Roccaro, AM, Ghobrial, IM, Calvo, KR & Landgren, O 2014, 'Altered cytokine and chemokine profiles in multiple myeloma and its precursor disease', Cytokine, vol. 69, no. 2, pp. 294-297. https://doi.org/10.1016/j.cyto.2014.05.017

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abstract = "Currently, no reliable biomarkers are available to predict transformation from smoldering myeloma (SMM) to multiple myeloma (MM). Using an ultrasensitive enzyme-linked immunosorbent assay (ELISA) we assessed the levels of a broad range of cytokines and chemokines in the peripheral blood (PB) and bone marrow (BM) supernatant collected from 14 SMM and 38 MM patients and compared to healthy donors. We found significantly increased levels of key cytokines, in particular CXCL8 (IL-8), associated with progressive disease state (controls → SMM → MM). Cytokine profiles were found similar in PB and BM. Five of fourteen SMM patients (36%) progressed to MM.Our findings, although based on a limited number of patients, suggest that serum-based cytokines may have a future role as biomarkers for disease progression and could potentially be assessed as novel targets for treatment.",

keywords = "CXCL8, Chemokines, Multiple myeloma",

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AU - Zingone, Adriana

AU - Wang, Weixin

AU - Corrigan-Cummins, Meghan

AU - Wu, S. Peter

AU - Plyler, Ryan

AU - Korde, Neha

AU - Kwok, Mary

AU - Manasanch, Elisabet E.

AU - Tageja, Nishant

AU - Bhutani, Manisha

AU - Mulquin, Marcia

AU - Zuchlinski, Diamond

AU - Yancey, Mary Ann

AU - Roschewski, Mark

AU - Zhang, Yong

AU - Roccaro, Aldo M.

AU - Ghobrial, Irene M.

AU - Calvo, Katherine R.

AU - Landgren, Ola

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Currently, no reliable biomarkers are available to predict transformation from smoldering myeloma (SMM) to multiple myeloma (MM). Using an ultrasensitive enzyme-linked immunosorbent assay (ELISA) we assessed the levels of a broad range of cytokines and chemokines in the peripheral blood (PB) and bone marrow (BM) supernatant collected from 14 SMM and 38 MM patients and compared to healthy donors. We found significantly increased levels of key cytokines, in particular CXCL8 (IL-8), associated with progressive disease state (controls → SMM → MM). Cytokine profiles were found similar in PB and BM. Five of fourteen SMM patients (36%) progressed to MM.Our findings, although based on a limited number of patients, suggest that serum-based cytokines may have a future role as biomarkers for disease progression and could potentially be assessed as novel targets for treatment.

AB - Currently, no reliable biomarkers are available to predict transformation from smoldering myeloma (SMM) to multiple myeloma (MM). Using an ultrasensitive enzyme-linked immunosorbent assay (ELISA) we assessed the levels of a broad range of cytokines and chemokines in the peripheral blood (PB) and bone marrow (BM) supernatant collected from 14 SMM and 38 MM patients and compared to healthy donors. We found significantly increased levels of key cytokines, in particular CXCL8 (IL-8), associated with progressive disease state (controls → SMM → MM). Cytokine profiles were found similar in PB and BM. Five of fourteen SMM patients (36%) progressed to MM.Our findings, although based on a limited number of patients, suggest that serum-based cytokines may have a future role as biomarkers for disease progression and could potentially be assessed as novel targets for treatment.

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Altered cytokine and chemokine profiles in multiple myeloma and its precursor disease

Abstract

Keywords

ASJC Scopus subject areas

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