Alternative response criteria and clinical risk factors for assessing tumor response in patients with metastatic renal cell carcinoma who are receiving salvage therapy

Hyunseon C. Kang, Shiva Gupta, Wei Wei, Lina Lu, Marc R. Matrana, Nizar M. Tannir, Haesun Choi

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

OBJECTIVE. The purpose of this study is to compare the prognostic value of various solid tumor response criteria as well as the additive value of clinical risk factors in patients with advanced renal cell carcinoma (RCC). MATERIALS AND METHODS. Two sets of CT scans (pretreatment scans and scans obtained 1-3.5 months after treatment) were reviewed for 57 patients with metastatic RCC treated with pazopanib in the salvage setting. Tumor response on the posttherapy scan was evaluated using Response Evaluation Criteria in Solid Tumors (RECIST) and Choi, modified Choi (mChoi), MASS (Morphology, Attenuation, Size, and Structure), and 10% threshold criteria. In addition, combined Memorial Sloan-Kettering Cancer Center (MSKCC) risk factors plus imaging criteria were used to define response groups. Response evaluations using these criteria were correlated with overall survival (OS) and progression-free survival (PFS), with use of the log-rank test. RESULTS. Patients classified as having progressive disease (PD) on the basis of RECIST, mChoi, and MASS criteria had a significantly worse OS than patients with stable disease (SD) and partial response (PR). With the addition of MSKCC risk factors, all groups with PD defined by combined criteria had significantly worse OS. For 37 patients with no or one MSKCC risk factor, response groups defined by Choi, mChoi, MASS, and 10% threshold criteria did not differ in PFS or OS. However, among 20 patients with two to three MSKCC risk factors, those classified as having PR had longer PFS than did those with SD and had longer OS than did those with PD. CONCLUSION. For patients with advanced RCC for which prior therapies have failed, the prognostic value of various imaging-based tumor response criteria differs on the basis of the MSKCC clinical risk status.

Original languageEnglish (US)
Pages (from-to)1278-1284
Number of pages7
JournalAmerican Journal of Roentgenology
Volume209
Issue number6
DOIs
StatePublished - Dec 2017

Keywords

  • Clinical risk factors
  • Pazopanib
  • Renal cell carcinoma
  • Salvage therapy
  • Tumor response criteria

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

MD Anderson CCSG core facilities

  • Biostatistics Resource Group

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