TY - JOUR
T1 - An analysis of skin tests and their relationship to recurrence and survival in stage III and stage IV melanoma patients
AU - Lee, Elisa T.
AU - Ishmael, D. Richard
AU - Bottomley, Richard H.
AU - Murray, J. Lee
PY - 1982/6/1
Y1 - 1982/6/1
N2 - One‐hundred‐two patients with Stage III and IV malignant melanoma were analyzed to determine whether immunologic status in terms of skin testing along with sex and age played a role in recurrence and survival. Before treatment, patients had skin tests with five recall antigens (monilia, mumps, PPD, SK‐SD, trichophyton) along with phytohemagglutinin (PHA). Univariate statistical analysis revealed sex as the major significant variable with respect to survival for Stage IVB patients, with female patients surviving longer than males. Patients with resected disease and greater SK‐SD skin test reactivity tended to survive longer than those with impaired reactivity. Similarly, reactivity to trichophyton was associated with improved survival among patients with metastases. A multivariate analysis of the patients shows improved remission duration with mumps positivity in Stage III and Stage IVA patients. It appears that certain skin tests analyzed in this fashion have prognostic importance in these patients and should be analyzed with other variables of disease status.
AB - One‐hundred‐two patients with Stage III and IV malignant melanoma were analyzed to determine whether immunologic status in terms of skin testing along with sex and age played a role in recurrence and survival. Before treatment, patients had skin tests with five recall antigens (monilia, mumps, PPD, SK‐SD, trichophyton) along with phytohemagglutinin (PHA). Univariate statistical analysis revealed sex as the major significant variable with respect to survival for Stage IVB patients, with female patients surviving longer than males. Patients with resected disease and greater SK‐SD skin test reactivity tended to survive longer than those with impaired reactivity. Similarly, reactivity to trichophyton was associated with improved survival among patients with metastases. A multivariate analysis of the patients shows improved remission duration with mumps positivity in Stage III and Stage IVA patients. It appears that certain skin tests analyzed in this fashion have prognostic importance in these patients and should be analyzed with other variables of disease status.
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U2 - 10.1002/1097-0142(19820601)49:11<2336::AID-CNCR2820491121>3.0.CO;2-U
DO - 10.1002/1097-0142(19820601)49:11<2336::AID-CNCR2820491121>3.0.CO;2-U
M3 - Article
C2 - 7074548
AN - SCOPUS:0020044882
SN - 0008-543X
VL - 49
SP - 2336
EP - 2341
JO - Cancer
JF - Cancer
IS - 11
ER -