An easy and rapid method to determine aristolochic acids I and II with high sensitivity

Ziyi Sun; Lifang Liu; Xiaofeng Zheng; Chunhai Fan; Qiang Wang; Genxi Li

doi:10.1007/s00216-003-2209-2

An easy and rapid method to determine aristolochic acids I and II with high sensitivity

Ziyi Sun
, Lifang Liu
, Xiaofeng Zheng
, Chunhai Fan
, Qiang Wang
, Genxi Li

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Aristolochic acid (AA), a natural component in some Chinese medicinal plants, is nephrotoxic and carcinogenic, and is involved in a specific type of renal fibrosis, called Chinese herbs nephropathy (CHN). In this paper, we report the electrochemistry of AA and a novel method to detect the species based on the electrochemical studies. The detection limit is estimated to be 1.0×10^-8 M with a linear range from 5.0×10^-8 M to 1.3×10^-6 M. Meanwhile, this method is applicable in detection in real samples, such as Caulis Aristolochiae Manshuriensis (CAM), Radix Aristolochiae (RA), Fructus Aristolochiae (FA) and Radix Stephaniae Tetrandrae (RST). The concentration of AA in the CAM sample was 3.50±0.12×10^-4 M. Consistent results have been obtained from both the electrochemical approach described here and the previously reported HPLC method.

Original language	English (US)
Pages (from-to)	388-390
Number of pages	3
Journal	Analytical and Bioanalytical Chemistry
Volume	378
Issue number	2
DOIs	https://doi.org/10.1007/s00216-003-2209-2
State	Published - Jan 2004
Externally published	Yes

Keywords

Aristolochic acid
Caulis Aristolochiae Manshuriensis
Cyclic voltammetry
Determination

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

Access to Document

10.1007/s00216-003-2209-2

Cite this

@article{49e630a11039477c8196e9c196fd6a1e,

title = "An easy and rapid method to determine aristolochic acids I and II with high sensitivity",

abstract = "Aristolochic acid (AA), a natural component in some Chinese medicinal plants, is nephrotoxic and carcinogenic, and is involved in a specific type of renal fibrosis, called Chinese herbs nephropathy (CHN). In this paper, we report the electrochemistry of AA and a novel method to detect the species based on the electrochemical studies. The detection limit is estimated to be 1.0{\texttimes}10-8 M with a linear range from 5.0{\texttimes}10-8 M to 1.3{\texttimes}10-6 M. Meanwhile, this method is applicable in detection in real samples, such as Caulis Aristolochiae Manshuriensis (CAM), Radix Aristolochiae (RA), Fructus Aristolochiae (FA) and Radix Stephaniae Tetrandrae (RST). The concentration of AA in the CAM sample was 3.50±0.12{\texttimes}10-4 M. Consistent results have been obtained from both the electrochemical approach described here and the previously reported HPLC method.",

keywords = "Aristolochic acid, Caulis Aristolochiae Manshuriensis, Cyclic voltammetry, Determination",

author = "Ziyi Sun and Lifang Liu and Xiaofeng Zheng and Chunhai Fan and Qiang Wang and Genxi Li",

note = "Funding Information: Acknowledgements We greatly appreciate the support of the National Natural Science Foundation, and the Ministry of Education, P. R. China for this research.",

year = "2004",

month = jan,

doi = "10.1007/s00216-003-2209-2",

language = "English (US)",

volume = "378",

pages = "388--390",

journal = "Analytical and Bioanalytical Chemistry",

issn = "1618-2642",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "2",

}

TY - JOUR

T1 - An easy and rapid method to determine aristolochic acids I and II with high sensitivity

AU - Sun, Ziyi

AU - Liu, Lifang

AU - Zheng, Xiaofeng

AU - Fan, Chunhai

AU - Wang, Qiang

AU - Li, Genxi

N1 - Funding Information: Acknowledgements We greatly appreciate the support of the National Natural Science Foundation, and the Ministry of Education, P. R. China for this research.

PY - 2004/1

Y1 - 2004/1

N2 - Aristolochic acid (AA), a natural component in some Chinese medicinal plants, is nephrotoxic and carcinogenic, and is involved in a specific type of renal fibrosis, called Chinese herbs nephropathy (CHN). In this paper, we report the electrochemistry of AA and a novel method to detect the species based on the electrochemical studies. The detection limit is estimated to be 1.0×10-8 M with a linear range from 5.0×10-8 M to 1.3×10-6 M. Meanwhile, this method is applicable in detection in real samples, such as Caulis Aristolochiae Manshuriensis (CAM), Radix Aristolochiae (RA), Fructus Aristolochiae (FA) and Radix Stephaniae Tetrandrae (RST). The concentration of AA in the CAM sample was 3.50±0.12×10-4 M. Consistent results have been obtained from both the electrochemical approach described here and the previously reported HPLC method.

AB - Aristolochic acid (AA), a natural component in some Chinese medicinal plants, is nephrotoxic and carcinogenic, and is involved in a specific type of renal fibrosis, called Chinese herbs nephropathy (CHN). In this paper, we report the electrochemistry of AA and a novel method to detect the species based on the electrochemical studies. The detection limit is estimated to be 1.0×10-8 M with a linear range from 5.0×10-8 M to 1.3×10-6 M. Meanwhile, this method is applicable in detection in real samples, such as Caulis Aristolochiae Manshuriensis (CAM), Radix Aristolochiae (RA), Fructus Aristolochiae (FA) and Radix Stephaniae Tetrandrae (RST). The concentration of AA in the CAM sample was 3.50±0.12×10-4 M. Consistent results have been obtained from both the electrochemical approach described here and the previously reported HPLC method.

KW - Aristolochic acid

KW - Caulis Aristolochiae Manshuriensis

KW - Cyclic voltammetry

KW - Determination

UR - https://www.scopus.com/pages/publications/3042578179

UR - https://www.scopus.com/pages/publications/3042578179#tab=citedBy

U2 - 10.1007/s00216-003-2209-2

DO - 10.1007/s00216-003-2209-2

M3 - Article

C2 - 13680054

AN - SCOPUS:3042578179

SN - 1618-2642

VL - 378

SP - 388

EP - 390

JO - Analytical and Bioanalytical Chemistry

JF - Analytical and Bioanalytical Chemistry

IS - 2

ER -

An easy and rapid method to determine aristolochic acids I and II with high sensitivity

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this