An MRI-sensitive, non-photobleachable porphysome photothermal agent

Thomas D. Macdonald, Tracy Liu, Gang Zheng

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Photothermal therapy makes use of photothermal sensitizers and laser light to thermally ablate diseased tissues. Porphysome nanoparticles offer a nontoxic alternative to inorganic nanocrystals for the efficient conversion of light into heat. Mn3+ ions were incorporated directly into the building blocks of our porphysome nanoparticles, thus imparting MRI sensitivity while simultaneously improving photostability and maintaining high photothermal efficiency. Mn porphysomes are as photothermally effective as free-base porphysomes and can rival gadolinium diethylenetriaminepentaacetate (Gd-DTPA) for MRI contrast generation. Their MRI contrast generation, photothermal efficiency, and photostability are unprecedented for an all-organic nanoparticle composed of a single functional component. Lights, camera, action: Photothermal therapy makes use of photothermal sensitizers and laser light to thermally ablate diseased tissues. Porphysome nanoparticles offer a nontoxic alternative to inorganic nanocrystals for the efficient conversion of light into heat. Mn3+ ions were incorporated into the building blocks of porphysome nanoparticles, thus imparting MRI sensitivity while improving photostability and maintaining high photothermal efficiency.

Original languageEnglish (US)
Pages (from-to)6956-6959
Number of pages4
JournalAngewandte Chemie - International Edition
Volume53
Issue number27
DOIs
StatePublished - Jul 1 2014

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Magnetic resonance imaging
Nanoparticles
Nanocrystals
Ions
Tissue
Lasers
Gadolinium
Cameras
Hot Temperature

Keywords

  • manganese
  • nanoparticles
  • photostability
  • porphyrins
  • theranostics

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

An MRI-sensitive, non-photobleachable porphysome photothermal agent. / Macdonald, Thomas D.; Liu, Tracy; Zheng, Gang.

In: Angewandte Chemie - International Edition, Vol. 53, No. 27, 01.07.2014, p. 6956-6959.

Research output: Contribution to journalArticle

Macdonald, Thomas D. ; Liu, Tracy ; Zheng, Gang. / An MRI-sensitive, non-photobleachable porphysome photothermal agent. In: Angewandte Chemie - International Edition. 2014 ; Vol. 53, No. 27. pp. 6956-6959.
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