TY - JOUR
T1 - An overview of the design and conduct of the BATTLE trials
AU - Liu, Suyu
AU - Lee, J. Jack
N1 - Publisher Copyright:
© Chinese Clinical Oncology. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Our increasing knowledge of biomedicine and genomics for human malignancies has placed us within reach of achieving personalized cancer medicine. The Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE)-1 trial was the first completed, prospective biopsy-mandated, biomarker-based, adaptive randomized clinical trial for patients with advanced non-small cell lung cancer (NSCLC). The ongoing BATTLE-2 trial continues to search for effective targeted therapies by further refining the clinical trial design. The BATTLE program has demonstrated the feasibility and promise of novel biomarker-based clinical trial platforms, which has moved us one step closer to personalized medicine. In this paper, we describe the design and conduct of the BATTLE trials, summarize the main findings, and report the experiences and lessons learned from our pursuit of developing targeted therapies in cancer.
AB - Our increasing knowledge of biomedicine and genomics for human malignancies has placed us within reach of achieving personalized cancer medicine. The Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE)-1 trial was the first completed, prospective biopsy-mandated, biomarker-based, adaptive randomized clinical trial for patients with advanced non-small cell lung cancer (NSCLC). The ongoing BATTLE-2 trial continues to search for effective targeted therapies by further refining the clinical trial design. The BATTLE program has demonstrated the feasibility and promise of novel biomarker-based clinical trial platforms, which has moved us one step closer to personalized medicine. In this paper, we describe the design and conduct of the BATTLE trials, summarize the main findings, and report the experiences and lessons learned from our pursuit of developing targeted therapies in cancer.
KW - Bayesian adaptive designs
KW - Personalized medicine
KW - Predictive biomarkers
KW - Targeted therapies
UR - http://www.scopus.com/inward/record.url?scp=84960334957&partnerID=8YFLogxK
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U2 - 10.3978/j.issn.2304-3865.2015.06.07
DO - 10.3978/j.issn.2304-3865.2015.06.07
M3 - Review article
C2 - 26408300
AN - SCOPUS:84960334957
SN - 2304-3865
VL - 4
JO - Chinese clinical oncology
JF - Chinese clinical oncology
IS - 3
M1 - 33
ER -