TY - JOUR
T1 - An overview of tumor necrosis factor α and the failing human heart
AU - Torre-Amione, Guillermo
AU - Bozkurt, Biykem
AU - Deswal, Anita
AU - Mann, Douglas L.
PY - 1999
Y1 - 1999
N2 - Recent studies have identified the importance of biologically active molecules (eg, neurohormones) in disease progression in heart failure. In addition to neurohormones, another portfolio of biologically active molecules, termed cytokines, are also expressed in the setting of heart failure. This article reviews recent clinical and experimental material that suggest that the cytokines (eg, tumor necrosis factor α), much like the neurohormones, may represent another class of biologically active molecules that are responsible for the development and progression of heart failure.
AB - Recent studies have identified the importance of biologically active molecules (eg, neurohormones) in disease progression in heart failure. In addition to neurohormones, another portfolio of biologically active molecules, termed cytokines, are also expressed in the setting of heart failure. This article reviews recent clinical and experimental material that suggest that the cytokines (eg, tumor necrosis factor α), much like the neurohormones, may represent another class of biologically active molecules that are responsible for the development and progression of heart failure.
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U2 - 10.1097/00001573-199905000-00003
DO - 10.1097/00001573-199905000-00003
M3 - Review article
C2 - 10358791
AN - SCOPUS:0032945406
SN - 0268-4705
VL - 14
SP - 206
EP - 210
JO - Current opinion in cardiology
JF - Current opinion in cardiology
IS - 3
ER -