Analysis of prognostic factors associated with survival in men with prostate cancer accompanied by spinal metastases at first diagnosis

Luling Shan, Xiuxin Han, Chao Zhang, Zhiwu Ren, Shoulei Liang, Guowen Wang

    Research output: Contribution to journalArticle

    Abstract

    Objective: Prostate cancer frequently metastasizes to the spine. In this study, we investigate the prognostic factors associated with survival in patients with prostate cancer accompanied by spinal metastases at their preliminary diagnosis. Methods: Clinical data of 49 patients who were diagnosed with spinal metastasis from prostate cancer between January 2005 and December 2010 were analyzed. Variables including alkaline phosphatase (ALP), previous skeletal-related event, Gleason score, prostate-specific antigen (PSA) nadir, and time to castration resistance were obtained. Moreover, the relationship between these variables and overall survival (OS) was analyzed. Survival analysis was performed by using Kaplan-Meier curves. Furthermore, the differences among the OS rates were assessed by using the log rank test. The variables were statistically significant in the univariate analysis (P<0.05) and were included in the multivariate model. Results: The average follow-up time was 64.1 months among the 49 patients. By the end of the follow-up, 41 of these patients were dead; the mean survival was 27 months. The 1-, 3-, and 5-year survival rate was 81.6%, 40.8%, and 20.4%, respectively. Univariate analysis identified that 6 variables were statistically significant prognostic factors of OS: with or without chemotherapy, ALP, previous skeletal-related event, Gleason score, PSA nadir, and time to castration resistance. The multivariate analysis showed that the time to castration resistance of ≥19 months and the addition of chemotherapy after disease progression are independent prognostic factors for a high OS. Conclusion: With or without chemotherapy and the time to castration resistance are the independent prognostic factors associated with survival in patients with prostate cancer accompanied by spinal metastases at first diagnosis.

    Original languageEnglish (US)
    Pages (from-to)862-865
    Number of pages4
    JournalChinese Journal of Clinical Oncology
    Volume42
    Issue number17
    DOIs
    StatePublished - Jan 1 2015

      Fingerprint

    Keywords

    • Chemotherapy
    • Endocrine therapy
    • Prognosis
    • Prostate cancer
    • Spinal metastasis

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

    Cite this