Analysis of Y chromosome nucleolar organizer mutants in Drosophilamelanogaster

Varsha V. Gandhi; Zelton D. Sharp; James D. Procunier

doi:10.1016/0006-291X(82)90705-7

Analysis of Y chromosome nucleolar organizer mutants in Drosophilamelanogaster

Varsha V. Gandhi, Zelton D. Sharp, James D. Procunier

Experimental Therapeutics

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6 Scopus citations

Abstract

Five Y chromosome nucleolar organizer (Y-NO) mutants were analyzed with respect to their rRNA gene numbers, phenotypes and additivity tests with other NO mutants. Four of these are indicative of a class of mutants in which most of the rRNA genes are transcribing functional rRNA. The other mutant has 80 genes, however, lethality and additivity tests suggests that many if not all of these rRNA genes are non-functional. The basis for the observed suppression of rRNA genes of the Y-NO region is discussed.

Original language	English (US)
Pages (from-to)	778-784
Number of pages	7
Journal	Biochemical and biophysical research communications
Volume	104
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(82)90705-7
State	Published - Jan 29 1982

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Analysis of Y chromosome nucleolar organizer mutants in Drosophilamelanogaster",

abstract = "Five Y chromosome nucleolar organizer (Y-NO) mutants were analyzed with respect to their rRNA gene numbers, phenotypes and additivity tests with other NO mutants. Four of these are indicative of a class of mutants in which most of the rRNA genes are transcribing functional rRNA. The other mutant has 80 genes, however, lethality and additivity tests suggests that many if not all of these rRNA genes are non-functional. The basis for the observed suppression of rRNA genes of the Y-NO region is discussed.",

author = "Gandhi, {Varsha V.} and Sharp, {Zelton D.} and Procunier, {James D.}",

note = "Funding Information: This work was supported by Public Health",

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AU - Gandhi, Varsha V.

AU - Sharp, Zelton D.

AU - Procunier, James D.

N1 - Funding Information: This work was supported by Public Health

PY - 1982/1/29

Y1 - 1982/1/29

N2 - Five Y chromosome nucleolar organizer (Y-NO) mutants were analyzed with respect to their rRNA gene numbers, phenotypes and additivity tests with other NO mutants. Four of these are indicative of a class of mutants in which most of the rRNA genes are transcribing functional rRNA. The other mutant has 80 genes, however, lethality and additivity tests suggests that many if not all of these rRNA genes are non-functional. The basis for the observed suppression of rRNA genes of the Y-NO region is discussed.

AB - Five Y chromosome nucleolar organizer (Y-NO) mutants were analyzed with respect to their rRNA gene numbers, phenotypes and additivity tests with other NO mutants. Four of these are indicative of a class of mutants in which most of the rRNA genes are transcribing functional rRNA. The other mutant has 80 genes, however, lethality and additivity tests suggests that many if not all of these rRNA genes are non-functional. The basis for the observed suppression of rRNA genes of the Y-NO region is discussed.

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Analysis of Y chromosome nucleolar organizer mutants in Drosophilamelanogaster

Abstract

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