Anaplastic carcinoma prognosis

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


All studies that have examined the outcome of patients with anaplastic carcinoma have demonstrated the bleak prognosis associated with this disease. Product-limit estimates of median survival from diagnosis range from 3 to 7 mo, and the 1-and 5-yr survival probabilities are 20-35% and 5-10%, respectively (1-6). The cause of death is related to upper airway obstruction and suffocation in 50-60% (often despite the presence of a tracheostomy), along with a combination of complications of local and distant disease in the remaining patients (2,7). Examination of survival curves from these studies reveals two distinct components: a sharp initial decline for the first 18-24 mo, followed by a slower rate of death over the ensuing years (Fig. 1). Perhaps 5% of patients with anaplastic carcinoma may survive many years after initial diagnosis and treatment without evidence of recurrent disease (2,6).

Original languageEnglish (US)
Title of host publicationThyroid Cancer (Second Edition)
Subtitle of host publicationA Comprehensive Guide to Clinical Management
PublisherHumana Press
Number of pages3
ISBN (Print)9781588294623
StatePublished - 2006

ASJC Scopus subject areas

  • Medicine(all)


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