TY - JOUR
T1 - Angiogenesis in melanoma
T2 - An update with a focus on current targeted therapies
AU - Jour, George
AU - Ivan, Doina
AU - Aung, Phyu P.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/6
Y1 - 2016/6
N2 - Angiogenesis plays a crucial role in melanoma metastasis and progression. In recent years, numerous studies have investigated the prognostic and clinical significance of this phenomenon, and the development of molecular techniques has enabled us to achieve a better understanding of angiogenesis in melanoma. Herein, we review the current state of knowledge regarding angiogenesis in melanoma, including the pathophysiological, histological and immunohistochemical aspects of this phenomenon. We also review the molecular pathways involved in angiogenesis and the interplay between different components that might be manipulated in the future development of efficient targeted therapies. Recently developed targeted antiangiogenic therapies in clinical trials and included in the treatment of advanced-stage melanoma are also reviewed.
AB - Angiogenesis plays a crucial role in melanoma metastasis and progression. In recent years, numerous studies have investigated the prognostic and clinical significance of this phenomenon, and the development of molecular techniques has enabled us to achieve a better understanding of angiogenesis in melanoma. Herein, we review the current state of knowledge regarding angiogenesis in melanoma, including the pathophysiological, histological and immunohistochemical aspects of this phenomenon. We also review the molecular pathways involved in angiogenesis and the interplay between different components that might be manipulated in the future development of efficient targeted therapies. Recently developed targeted antiangiogenic therapies in clinical trials and included in the treatment of advanced-stage melanoma are also reviewed.
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U2 - 10.1136/jclinpath-2015-203482
DO - 10.1136/jclinpath-2015-203482
M3 - Review article
C2 - 26865640
AN - SCOPUS:84959175035
SN - 0021-9746
VL - 69
SP - 472
EP - 483
JO - Journal of Clinical Pathology
JF - Journal of Clinical Pathology
IS - 6
ER -