Abstract
Angioimmunoblastic T-cell lymphoma (AITL) carries genetic mutations of TET2, RHOA, and IDH2, but the prognostic impact of these mutations is not widely investigated. Although one study shows no difference in overall survival between patients with or without RHOA G17V mutation, a poor performance status is associated with RHOA G17V-mutated AITL, which is an independent adverse factor. We retrospectively investigated the prognostic impact of RHOA G17V mutation in AITL patients. A total of 31 cases were enrolled (male-to-female, 2.1; mean age: 62.8 years). RHOA G17V mutation was analyzed by deep sequencing. We found that in contrast to RHOA-wild type, patients with RHOA G17V-mutated AITL more frequently had B symptoms (p =.035), stronger PD1 expression (p =.045), ≥3 TFH markers (p =.011), higher blood vessel density (p<.001), and poorer progression-free survival (p =.046). These results support a role for RHOA genetic testing in AITL patients as ROHA G17V mutation carries a worse prognosis, probably associated with B symptoms and stage IV disease.
Original language | English (US) |
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Pages (from-to) | 1108-1118 |
Number of pages | 11 |
Journal | Leukemia and Lymphoma |
Volume | 61 |
Issue number | 5 |
DOIs | |
State | Published - Apr 15 2020 |
Keywords
- Angioimmunoblastic T-cell lymphoma (AITL)
- ROHA G17V mutation
- clinical features
- next generation sequencing
- prognosis
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research