Antagonism between Antiviral Signaling and Glycolysis

Anoop Singh Chauhan; Li Zhuang; Boyi Gan

doi:10.1016/j.tem.2019.07.010

Antagonism between Antiviral Signaling and Glycolysis

Anoop Singh Chauhan, Li Zhuang, Boyi Gan

Experimental Radiation Oncology

Research output: Contribution to journal › Short survey › peer-review

10 Scopus citations

Abstract

RIG-I-like receptor (RLR)-mediated interferon production is critical for antiviral responses. A recent study (Zhang et al., Cell, 2019) uncovered a reciprocal inhibition between RLR signaling and glycolysis: lactate produced by glycolysis inhibits RLR signaling by binding to RLR signaling component mitochondrial antiviral-signaling (MAVS), whereas RLR activation suppresses glycolysis through inhibiting glycolysis enzyme hexokinase.

Original language	English (US)
Pages (from-to)	571-573
Number of pages	3
Journal	Trends in Endocrinology and Metabolism
Volume	30
Issue number	9
DOIs	https://doi.org/10.1016/j.tem.2019.07.010
State	Published - Sep 2019

Keywords

LDHA
MAVS
RLR signaling
glycolysis
lactate

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.tem.2019.07.010

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title = "Antagonism between Antiviral Signaling and Glycolysis",

abstract = "RIG-I-like receptor (RLR)-mediated interferon production is critical for antiviral responses. A recent study (Zhang et al., Cell, 2019) uncovered a reciprocal inhibition between RLR signaling and glycolysis: lactate produced by glycolysis inhibits RLR signaling by binding to RLR signaling component mitochondrial antiviral-signaling (MAVS), whereas RLR activation suppresses glycolysis through inhibiting glycolysis enzyme hexokinase.",

keywords = "LDHA, MAVS, RLR signaling, glycolysis, lactate",

author = "Chauhan, {Anoop Singh} and Li Zhuang and Boyi Gan",

note = "Funding Information: B.G. thanks Amy Ninetto from Scientific Publications at The University of Texas MD Anderson Cancer Center for manuscript editing. B.G. is supported by National Institutes of Health (NIH) grants R01CA181196 and P30CA016672. Funding Information: B.G. thanks Amy Ninetto from Scientific Publications at The University of Texas MD Anderson Cancer Center for manuscript editing. B.G. is supported by National Institutes of Health (NIH) grants R01CA181196 and P30CA016672 . Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = sep,

doi = "10.1016/j.tem.2019.07.010",

language = "English (US)",

volume = "30",

pages = "571--573",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Inc.",

number = "9",

}

TY - JOUR

T1 - Antagonism between Antiviral Signaling and Glycolysis

AU - Chauhan, Anoop Singh

AU - Zhuang, Li

AU - Gan, Boyi

N1 - Funding Information: B.G. thanks Amy Ninetto from Scientific Publications at The University of Texas MD Anderson Cancer Center for manuscript editing. B.G. is supported by National Institutes of Health (NIH) grants R01CA181196 and P30CA016672. Funding Information: B.G. thanks Amy Ninetto from Scientific Publications at The University of Texas MD Anderson Cancer Center for manuscript editing. B.G. is supported by National Institutes of Health (NIH) grants R01CA181196 and P30CA016672 . Publisher Copyright: © 2019 Elsevier Ltd

PY - 2019/9

Y1 - 2019/9

N2 - RIG-I-like receptor (RLR)-mediated interferon production is critical for antiviral responses. A recent study (Zhang et al., Cell, 2019) uncovered a reciprocal inhibition between RLR signaling and glycolysis: lactate produced by glycolysis inhibits RLR signaling by binding to RLR signaling component mitochondrial antiviral-signaling (MAVS), whereas RLR activation suppresses glycolysis through inhibiting glycolysis enzyme hexokinase.

AB - RIG-I-like receptor (RLR)-mediated interferon production is critical for antiviral responses. A recent study (Zhang et al., Cell, 2019) uncovered a reciprocal inhibition between RLR signaling and glycolysis: lactate produced by glycolysis inhibits RLR signaling by binding to RLR signaling component mitochondrial antiviral-signaling (MAVS), whereas RLR activation suppresses glycolysis through inhibiting glycolysis enzyme hexokinase.

KW - LDHA

KW - MAVS

KW - RLR signaling

KW - glycolysis

KW - lactate

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U2 - 10.1016/j.tem.2019.07.010

DO - 10.1016/j.tem.2019.07.010

M3 - Short survey

C2 - 31349923

AN - SCOPUS:85069735698

SN - 1043-2760

VL - 30

SP - 571

EP - 573

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 9

ER -

Antagonism between Antiviral Signaling and Glycolysis

Abstract

Keywords

ASJC Scopus subject areas

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