Anti-inflammatory principles from the stem and root barks of Citrus medica

Yu Yi Chan, Chan Hao Li, Yuh Chiang Shen, Tian Shung Wu

    Research output: Contribution to journalArticlepeer-review

    35 Scopus citations

    Abstract

    Bioassay-guided investigation of the anti-inflammatory principles from the stem and root barks of Citrus medica L. var. sarcodactylis SWINGLE has led to the isolation of a new coumarin, namely citrumedin-B (1) and thirty known compounds. The anti-inflammatory components were xanthyletin (2), nordentatin (3), atalantoflavon (4) and lonchocarpol A (5) which displayed potent nitric oxide (NO)-reducing activity in microglial cells. The structure of this new compound was completely elucidated using a combination of 2D NMR techniques (correlation spectroscopy (COSY), nuclear Overhauser effect spectroscopy (NOESY), heteronuclear multiple quantum coherence (HMQC) and heteronuclear multiple bond connectivity (HMBC)) and HR-electrospray ionization (ESI)-MS analyses. The known compounds were identified by comparison of their spectroscopic and physical data with those reported in the literature. These results can be inferred from the treatment of allergic response and inflammatory properties of Citrus medica L. var. sarcodactylis SWINGLE in traditional Chinese medicine.

    Original languageEnglish (US)
    Pages (from-to)61-65
    Number of pages5
    JournalChemical and Pharmaceutical Bulletin
    Volume58
    Issue number1
    DOIs
    StatePublished - Jan 2010

    Keywords

    • Anti-inflammatory activity
    • Citrumedin-B
    • Citrus medica L. var. sarcodactylis
    • Coumarin
    • Rutacae

    ASJC Scopus subject areas

    • Chemistry(all)
    • Drug Discovery

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