Antibody-dependent cell-mediated effects in bancroftian filariasis

K. Mehta, R. K. Sindhu, D. Subrahmanyam, K. Hopper, D. S. Nelson, C. K. Rao

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The nature of immunoglobulin and effector cells involved in the antibody-dependent cell-mediated adhesion and cytotoxicity to Wuchereria bancrofti larvae has been investigated. Human neutrophils and eosinophils purified from peripheral blood by metrizamide gradients readily adhered to the parasites in presence of IgG fraction of sera from majority of elephantiasis cases with amicrofilaraemia and many of the endemic normals. The cells from normal, microfilariae carriers and elephantiasis cases were equally effective in the adhesion reaction. While the adhered neutrophils killed the larvae, eosinophils were ineffective in this respect. DEC treatment of elephantiasis cases results in a significant reduction in the ability of their sera to promote cellular adhesion.

Original languageEnglish (US)
Pages (from-to)117-123
Number of pages7
JournalImmunology
Volume43
Issue number1
StatePublished - 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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