Antigen-specific human T cell factors. I. T cell helper factor: Biologic properties

C. J. Heijnen, F. Uytdehaag, K. H. Pot, R. E. Ballieux

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The in vitro induction and assay of an ovalbumin-specific human T cell helper factor are described. Peripheral blood T cells, cultured with ovalbumin in a Marbrook-Diener system, produce an antigen-specific factor (ThF(120)-OA), which can be purified by affinity chromatography. The in vitro studies with ThF(120)-OA pointed out that in the production of the factor as well as in the factor-B cell interaction the adherent cell determines the genetic restriction. The results of kinetic studies on T helper activities demonstrated that ThF (120)-OA provides an auxiliary activity at various moments during the differentiation of the human peripheral B cell into an antibody-secreting cell. The observed differences in the mode of action of Th cells and Th factor are discussed.

Original languageEnglish (US)
Pages (from-to)497-502
Number of pages6
JournalJournal of Immunology
Volume126
Issue number2
StatePublished - 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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