Abstract
The in vitro induction and assay of an ovalbumin-specific human T cell helper factor are described. Peripheral blood T cells, cultured with ovalbumin in a Marbrook-Diener system, produce an antigen-specific factor (ThF(120)-OA), which can be purified by affinity chromatography. The in vitro studies with ThF(120)-OA pointed out that in the production of the factor as well as in the factor-B cell interaction the adherent cell determines the genetic restriction. The results of kinetic studies on T helper activities demonstrated that ThF (120)-OA provides an auxiliary activity at various moments during the differentiation of the human peripheral B cell into an antibody-secreting cell. The observed differences in the mode of action of Th cells and Th factor are discussed.
Original language | English (US) |
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Pages (from-to) | 497-502 |
Number of pages | 6 |
Journal | Journal of Immunology |
Volume | 126 |
Issue number | 2 |
State | Published - 1981 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology