Antigen-specific human T cell factors. II. T cell suppressor factor: Biologic properties

F. Uytdehaag; C. J. Heijnen; K. H. Pot; R. E. Ballieux

Antigen-specific human T cell factors. II. T cell suppressor factor: Biologic properties

F. Uytdehaag, C. J. Heijnen, K. H. Pot, R. E. Ballieux

Research output: Contribution to journal › Article › peer-review

Abstract

The in vitro induction of an ovalbumin-specific human T cell suppressor factor is described (TsF(120)-OA). The antigen-specific suppressive component can be purified by affinity chromatography from supernatants derived from Marbrook-Diener type cultures of peripheral blood T cells stimulated with a high dose of ovalbumin. TsF(120)-OA suppresses the antigen-induced PFC formation of human blood B cells in vitro in an antigen-specific way. The target of TsF(120)-OA activity is shown to be the T helper cell. No genetic restriction in the action of the factor is observed.

Original language	English (US)
Pages (from-to)	503-507
Number of pages	5
Journal	Journal of Immunology
Volume	126
Issue number	2
State	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

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title = "Antigen-specific human T cell factors. II. T cell suppressor factor: Biologic properties",

abstract = "The in vitro induction of an ovalbumin-specific human T cell suppressor factor is described (TsF(120)-OA). The antigen-specific suppressive component can be purified by affinity chromatography from supernatants derived from Marbrook-Diener type cultures of peripheral blood T cells stimulated with a high dose of ovalbumin. TsF(120)-OA suppresses the antigen-induced PFC formation of human blood B cells in vitro in an antigen-specific way. The target of TsF(120)-OA activity is shown to be the T helper cell. No genetic restriction in the action of the factor is observed.",

author = "F. Uytdehaag and Heijnen, {C. J.} and Pot, {K. H.} and Ballieux, {R. E.}",

year = "1981",

language = "English (US)",

volume = "126",

pages = "503--507",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "American Association of Immunologists",

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T1 - Antigen-specific human T cell factors. II. T cell suppressor factor

T2 - Biologic properties

AU - Uytdehaag, F.

AU - Heijnen, C. J.

AU - Pot, K. H.

AU - Ballieux, R. E.

PY - 1981

Y1 - 1981

N2 - The in vitro induction of an ovalbumin-specific human T cell suppressor factor is described (TsF(120)-OA). The antigen-specific suppressive component can be purified by affinity chromatography from supernatants derived from Marbrook-Diener type cultures of peripheral blood T cells stimulated with a high dose of ovalbumin. TsF(120)-OA suppresses the antigen-induced PFC formation of human blood B cells in vitro in an antigen-specific way. The target of TsF(120)-OA activity is shown to be the T helper cell. No genetic restriction in the action of the factor is observed.

AB - The in vitro induction of an ovalbumin-specific human T cell suppressor factor is described (TsF(120)-OA). The antigen-specific suppressive component can be purified by affinity chromatography from supernatants derived from Marbrook-Diener type cultures of peripheral blood T cells stimulated with a high dose of ovalbumin. TsF(120)-OA suppresses the antigen-induced PFC formation of human blood B cells in vitro in an antigen-specific way. The target of TsF(120)-OA activity is shown to be the T helper cell. No genetic restriction in the action of the factor is observed.

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M3 - Article

C2 - 6161176

AN - SCOPUS:0019491583

SN - 0022-1767

VL - 126

SP - 503

EP - 507

JO - Journal of Immunology

JF - Journal of Immunology

IS - 2

ER -

Antigen-specific human T cell factors. II. T cell suppressor factor: Biologic properties

Abstract

ASJC Scopus subject areas

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