Antileukemic Properties of Organoplatinum Complexes

Sandra J. Meischen; Glen R. Gale; Loretta M. Atkins; Alayne B. Smith

doi:10.1093/jnci/57.4.841

Antileukemic Properties of Organoplatinum Complexes

Sandra J. Meischen, Glen R. Gale, Loretta M. Atkins, Alayne B. Smith

Experimental Therapeutics

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51 Scopus citations

Abstract

The antitumor activity of 46 cis-amineplatinum congeners was evaluated against L1210 leukemia in (C57BL/6 × DBA/2)F₁mice. Several compounds in this series significantly prolonged the life-spans of mice with the leukemia. During the selection of the compound that yielded optimal activity [dichloro (1, 2-diaminocyclohexane)platinum], the chlorides were substituted with various organic and inorganic anions. The aqueous solubility was greatly increased with retention of significant antileukemic activity. Most of the active compounds were synergistic with cyclophosphamide, and cure rates up to 80% were obtained with certain combinations.

Original language	English (US)
Pages (from-to)	841-845
Number of pages	5
Journal	Journal of the National Cancer Institute
Volume	57
Issue number	4
DOIs	https://doi.org/10.1093/jnci/57.4.841
State	Published - Oct 1976

ASJC Scopus subject areas

Cancer Research
Oncology

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abstract = "The antitumor activity of 46 cis-amineplatinum congeners was evaluated against L1210 leukemia in (C57BL/6 × DBA/2)F1mice. Several compounds in this series significantly prolonged the life-spans of mice with the leukemia. During the selection of the compound that yielded optimal activity [dichloro (1, 2-diaminocyclohexane)platinum], the chlorides were substituted with various organic and inorganic anions. The aqueous solubility was greatly increased with retention of significant antileukemic activity. Most of the active compounds were synergistic with cyclophosphamide, and cure rates up to 80% were obtained with certain combinations.",

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AU - Meischen, Sandra J.

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AB - The antitumor activity of 46 cis-amineplatinum congeners was evaluated against L1210 leukemia in (C57BL/6 × DBA/2)F1mice. Several compounds in this series significantly prolonged the life-spans of mice with the leukemia. During the selection of the compound that yielded optimal activity [dichloro (1, 2-diaminocyclohexane)platinum], the chlorides were substituted with various organic and inorganic anions. The aqueous solubility was greatly increased with retention of significant antileukemic activity. Most of the active compounds were synergistic with cyclophosphamide, and cure rates up to 80% were obtained with certain combinations.

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Antileukemic Properties of Organoplatinum Complexes

Abstract

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