TY - JOUR
T1 - Antiplatelet therapy in atrophie blanche and livedo vasculitis
AU - Drucker, Carol R.
AU - Duncan, W. Christopher
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1982
Y1 - 1982
N2 - Seven patients with atrophie blanche or livedo vasculitis of the lower extremities showed abnormal platelet functions in vitro. Six of seven showed hyperaggregation with epinephrine and/or collagen, three showed increased platelet adhesiveness, three showed increased platelet count, and one showed increased microemboli. After treatment with dipyridamole and aspirin, all showed return to normal platelet function. Clinical improvement occurred in all patients, with significant alleviation of pain and decrease in new lesion formation. Although enhanced healing of lesions seemed evident to physician and patient, it was incomplete. In two patients, pain returned when dipyridamole and aspirin were stopped, but the patients improved again when the medicines were restarted. These preliminary findings indicate a possible beneficial effect of antiplatelet therapy in atrophie blanche and livedo vasculitis. A double-blind study is being undertaken to further study this effect.
AB - Seven patients with atrophie blanche or livedo vasculitis of the lower extremities showed abnormal platelet functions in vitro. Six of seven showed hyperaggregation with epinephrine and/or collagen, three showed increased platelet adhesiveness, three showed increased platelet count, and one showed increased microemboli. After treatment with dipyridamole and aspirin, all showed return to normal platelet function. Clinical improvement occurred in all patients, with significant alleviation of pain and decrease in new lesion formation. Although enhanced healing of lesions seemed evident to physician and patient, it was incomplete. In two patients, pain returned when dipyridamole and aspirin were stopped, but the patients improved again when the medicines were restarted. These preliminary findings indicate a possible beneficial effect of antiplatelet therapy in atrophie blanche and livedo vasculitis. A double-blind study is being undertaken to further study this effect.
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U2 - 10.1016/S0190-9622(82)70123-9
DO - 10.1016/S0190-9622(82)70123-9
M3 - Article
C2 - 7130497
AN - SCOPUS:0019994657
SN - 0190-9622
VL - 7
SP - 359
EP - 363
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 3
ER -