APAatlas: decoding alternative polyadenylation across human tissues

Wei Hong, Hang Ruan, Zhao Zhang, Youqiong Ye, Yaoming Liu, Shengli Li, Ying Jing, Huiwen Zhang, Lixia Diao, Han Liang, Leng Han

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Alternative polyadenylation (APA) is an RNA-processing mechanism on the 3' terminus that generates distinct isoforms of mRNAs and/or other RNA polymerase II transcripts with different 3'UTR lengths. Widespread APA affects post-transcriptional gene regulation in mRNA translation, stability, and localization, and exhibits strong tissue specificity. However, no existing database provides comprehensive information about APA events in a large number of human normal tissues. Using the RNA-seq data from the Genotype-Tissue Expression project, we systematically identified APA events from 9475 samples across 53 human tissues and examined their associations with multiple traits and gene expression across tissues. We further developed APAatlas, a user-friendly database (https://hanlab.uth.edu/apa/) for searching, browsing and downloading related information. APAatlas will help the biomedical research community elucidate the functions and mechanisms of APA events in human tissues.

Original languageEnglish (US)
Pages (from-to)D34-D39
JournalNucleic acids research
Volume48
Issue numberD1
DOIs
StatePublished - Jan 8 2020

ASJC Scopus subject areas

  • Genetics

MD Anderson CCSG core facilities

  • Bioinformatics Shared Resource

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