APO-1 (CD95) mediated apoptosis in human T-ALL engrafted in SCID mice

Klaus Michael Lücking-Famira, Peter T. Daniel, Peter Möller, Peter H. Krammer, Klaus Michael Debatin

    Research output: Contribution to journalArticle

    32 Scopus citations

    Abstract

    The monoclonal antibody anti-APO-1 induces apoptosis upon triggering the cell surface molecule APO-1 (CD95), a novel member of the tumor necrosis factor/nerve growth factor receptor superfamily. We tested the efficacy of APO-1 mediated apoptosis in a model system of human leukemia in SCID mice. T-ALL cells recovered from SCID mice were sensitive towards anti-APO-1 mediated apoptosis when tested in vitro. In vivo, treatment of leukemia-bearing SCID mice with anti-APO-1 induced programmed cell death in a substantial fraction of T-ALL cells, thus leading to significantly prolonged survival. Anti-APO-1 treatment, however, failed to completely eliminate all leukemic cells. This may be due to resistance towards anti-APO-1 mediated apoptosis in a fraction of T-ALL cells. Thus, identification of cellular programs which determine sensitivity and resistance towards apoptosis may provide new perspectives for rational therapeutic interventions.

    Original languageEnglish (US)
    Pages (from-to)1825-1833
    Number of pages9
    JournalLeukemia
    Volume8
    Issue number11
    StatePublished - Jan 1 1994

    ASJC Scopus subject areas

    • Hematology
    • Cancer Research
    • Anesthesiology and Pain Medicine

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    Lücking-Famira, K. M., Daniel, P. T., Möller, P., Krammer, P. H., & Debatin, K. M. (1994). APO-1 (CD95) mediated apoptosis in human T-ALL engrafted in SCID mice. Leukemia, 8(11), 1825-1833.