Apparent diffusion coefficient as a potential surrogate marker for Ki-67 index in mucinous breast carcinoma

Natsuko Onishi, Shotaro Kanao, Masako Kataoka, Mami Iima, Rena Sakaguchi, Makiko Kawai, Tatsuki R. Kataoka, Yoshiki Mikami, Masakazu Toi, Kaori Togashi

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    28 Scopus citations


    Purpose: To examine the association between apparent diffusion coefficient (ADC), cellularity, and Ki-67 index in mucinous breast carcinoma (MBC) compared with invasive carcinoma of no special type (NST). ADC's ability to identify lesions with highly proliferating MBC was also examined. Materials and Methods: Pathologically confirmed MBCs (mucinous group, n = 18) and NSTs (control group, n = 18) were retrospectively analyzed. ADC was calculated from signal intensity of diffusion-weighted imaging at b values of 0 and 1000 sec/mm2. The Ki-67 index and cellularity were histopathologically evaluated. The mucinous group was classified into high Ki-67 mucinous group (Ki-67 index ≤14%, highly proliferating) and low Ki-67 mucinous group. Results: In the mucinous group, minimum ADC (ADC-min) showed an inverse correlation with cellularity (r= -0.802, P < 0.0001) and Ki-67 index (r= -0.825, P < 0.0001). In the control group, ADCmin showed inverse correlation with cellularity (r= -0.537 P=0.022), but no correlation with Ki-67 index (r=0.035, P=0.892). ADC-min of high Ki-67 mucinous group was significantly lower than that of low Ki-67 mucinous group (P=0.005). Conclusion: This study demonstrates an inverse correlation between ADC and Ki-67 index in MBC and the ability of ADC to identify highly proliferating MBC. Considering that ADC can evaluate whole lesions noninvasively, ADC may be a promising noninvasive surrogate marker for Ki-67 index in the risk stratification of MBC.

    Original languageEnglish (US)
    Pages (from-to)610-615
    Number of pages6
    JournalJournal of Magnetic Resonance Imaging
    Issue number3
    StatePublished - Mar 1 2015



    • ADC
    • Breast cancer
    • Cellularity
    • Ki-67 index
    • Mucinous carcinoma

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

    Cite this

    Onishi, N., Kanao, S., Kataoka, M., Iima, M., Sakaguchi, R., Kawai, M., Kataoka, T. R., Mikami, Y., Toi, M., & Togashi, K. (2015). Apparent diffusion coefficient as a potential surrogate marker for Ki-67 index in mucinous breast carcinoma. Journal of Magnetic Resonance Imaging, 41(3), 610-615.