Applications of high- throughput analysis in therapeutic drug monitoring

Quanyun A. Xu, Timothy L. Madden

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter summarizes applications of high-throughput analysis in modern therapeutic drug monitoring. Today’s medicine has become increasingly personalized. To maximize drug efficacy and minimize drug toxicity, optimize treatment, and reduce costs, it is critical to monitor the concentrations of drugs in biological fluids collected from patients under medical management. Many analytical procedures have been developed for therapeutic drug monitoring. To analyze a large number of patient samples in a short time, as required by modern therapeutic drug monitoring, high-throughput analytical methods have been developed and validated. These methods include immunoassay via auto-immunoanalyzer, high performance liquid chromatography (HPLC) coupled with a unique monolithic column, online sample clean-up (column switching), and automated solid phase extraction.

Original languageEnglish (US)
Title of host publicationHigh-Throughput Analysis in the Pharmaceutical Industry
PublisherCRC Press
Pages299-318
Number of pages20
ISBN (Electronic)9781420059540
ISBN (Print)142005953X, 9781420059533
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Medicine(all)
  • Chemistry(all)

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