TY - JOUR
T1 - Appropriate duration of intravenous treatment of candidemia and timing of step down to oral therapy in non-neutropenic patients
AU - Dib, Rita Wilson
AU - Hachem, Ray
AU - Chaftari, Anne Marie
AU - Raad, Issam
N1 - Publisher Copyright:
© 2018.
PY - 2018
Y1 - 2018
N2 - In this review, we have analyzed the available literature pertaining to the total duration of intravenous (IV) therapy and the appropriate timing of step down to oral therapy in the management of candidemia. Overview of the guidelines and literature seem to indicate that a minimum of 14 days of antifungal therapy is required in the treatment of candidemia without deeply seated infection. However, this was never based on evidence. Furthermore, step down to oral therapy seems to be dependent on the clinical stability criteria of the patient with candidemia after 4 to 7 days of IV therapy. Further studies are required to evaluate the appropriate total duration of IV therapy, appropriate timing of step down to oral therapy and to validate the clinical criteria that would allow the switch to happen.
AB - In this review, we have analyzed the available literature pertaining to the total duration of intravenous (IV) therapy and the appropriate timing of step down to oral therapy in the management of candidemia. Overview of the guidelines and literature seem to indicate that a minimum of 14 days of antifungal therapy is required in the treatment of candidemia without deeply seated infection. However, this was never based on evidence. Furthermore, step down to oral therapy seems to be dependent on the clinical stability criteria of the patient with candidemia after 4 to 7 days of IV therapy. Further studies are required to evaluate the appropriate total duration of IV therapy, appropriate timing of step down to oral therapy and to validate the clinical criteria that would allow the switch to happen.
KW - Candidemia
KW - Intravenous treatment
KW - Non-nuetropenic patients
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U2 - 10.4084/MJHID.2018.028
DO - 10.4084/MJHID.2018.028
M3 - Article
C2 - 29755705
AN - SCOPUS:85049237488
SN - 2035-3006
VL - 10
JO - Mediterranean Journal of Hematology and Infectious Diseases
JF - Mediterranean Journal of Hematology and Infectious Diseases
IS - 1
M1 - e2018028
ER -