Aptamers as Insights for Targeting SARS-CoV-2

Suna Karadeniz Saygılı, Anna Szymanowska, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Paola Amero

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) continues to be a major cause of high mortality in the world. Despite many therapeutic approaches having been successfully developed, there is still the need to find novel and more effective therapeutic strategies to face the upcoming variants. Here, we will describe the potential use of aptamers, synthetic single-stranded oligonucleotides, as promising tools to target SARS-CoV-2. Since aptamers have been successfully developed against viruses, this review will focus on the latest selection approach method using artificial intelligence, the state-of-the-art in bioinformatics, and we will also summarize the latest discoveries in terms of aptamers against spike protein and other novel receptor proteins involved in SARS-CoV-2 entry and the use of single-cell transcriptomics to define novel promising targets for SARS-CoV-2.

Original languageEnglish (US)
Pages (from-to)116-137
Number of pages22
JournalBiologics
Volume3
Issue number2
DOIs
StatePublished - Jun 2023

Keywords

  • AXL
  • SARS-CoV-2
  • aptamers
  • artificial intelligence
  • single-cell transcriptomics
  • spike receptor
  • therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Immunology and Microbiology (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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