Are We There Yet? The Telltale Trail of ctDNA in Rectal Cancer

Alisha H. Bent; Arvind Dasari; J. Joshua Smith

doi:10.1158/1078-0432.CCR-25-2927

Are We There Yet? The Telltale Trail of ctDNA in Rectal Cancer

Alisha H. Bent
, Arvind Dasari
, J. Joshua Smith

GI Medical Oncology

Research output: Contribution to journal › Article › peer-review

Abstract

ctDNA has emerged as a noninvasive diagnostic and prognostic tool for colorectal cancer. The role of ctDNA in total neoadjuvant therapy and nonoperative management of locally advanced rectal cancer is uncertain. In this study, we discuss a ctDNA biomarker analysis of rectal cancer patients undergoing neoadjuvant therapy from the NOMINATE trial.

Original language	English (US)
Pages (from-to)	5117-5119
Number of pages	3
Journal	Clinical Cancer Research
Volume	31
Issue number	24
DOIs	https://doi.org/10.1158/1078-0432.CCR-25-2927
State	Published - Dec 15 2025

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1158/1078-0432.CCR-25-2927

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title = "Are We There Yet? The Telltale Trail of ctDNA in Rectal Cancer",

abstract = "ctDNA has emerged as a noninvasive diagnostic and prognostic tool for colorectal cancer. The role of ctDNA in total neoadjuvant therapy and nonoperative management of locally advanced rectal cancer is uncertain. In this study, we discuss a ctDNA biomarker analysis of rectal cancer patients undergoing neoadjuvant therapy from the NOMINATE trial.",

author = "Bent, \{Alisha H.\} and Arvind Dasari and \{Joshua Smith\}, J.",

note = "Publisher Copyright: {\textcopyright} 2025 American Association for Cancer Research.",

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AU - Bent, Alisha H.

AU - Dasari, Arvind

AU - Joshua Smith, J.

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Y1 - 2025/12/15

N2 - ctDNA has emerged as a noninvasive diagnostic and prognostic tool for colorectal cancer. The role of ctDNA in total neoadjuvant therapy and nonoperative management of locally advanced rectal cancer is uncertain. In this study, we discuss a ctDNA biomarker analysis of rectal cancer patients undergoing neoadjuvant therapy from the NOMINATE trial.

AB - ctDNA has emerged as a noninvasive diagnostic and prognostic tool for colorectal cancer. The role of ctDNA in total neoadjuvant therapy and nonoperative management of locally advanced rectal cancer is uncertain. In this study, we discuss a ctDNA biomarker analysis of rectal cancer patients undergoing neoadjuvant therapy from the NOMINATE trial.

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UR - https://www.scopus.com/pages/publications/105024997993#tab=citedBy

U2 - 10.1158/1078-0432.CCR-25-2927

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M3 - Article

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SN - 1078-0432

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EP - 5119

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 24

ER -

Are We There Yet? The Telltale Trail of ctDNA in Rectal Cancer

Abstract

ASJC Scopus subject areas

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