ARID1A mutation and genomic stability

Timothy Nacarelli; Bo Zhao; Xue Hao; Rugang Zhang

doi:10.1080/23723556.2019.1690923

ARID1A mutation and genomic stability

Timothy Nacarelli
, Bo Zhao
, Xue Hao
, Rugang Zhang

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1). ARID1A inactivation results in mitotic defects and negatively selects gross chromosomal aberrations, resulting in preservation of genomic stability in ARID1A-mutated cancers. These findings explain the long-standing paradox between mitotic defects caused by ARID1A inactivation and the lack of genomic instability in ARID1A-mutated cancers.

Original language	English (US)
Article number	1690923
Journal	Molecular and Cellular Oncology
Volume	7
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2019.1690923
State	Published - May 3 2020
Externally published	Yes

Keywords

ARID1A
genomic instability
mitotic defects
OCCC
STAG1
SWI/SNF
telomere

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2019.1690923

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title = "ARID1A mutation and genomic stability",

abstract = "We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1). ARID1A inactivation results in mitotic defects and negatively selects gross chromosomal aberrations, resulting in preservation of genomic stability in ARID1A-mutated cancers. These findings explain the long-standing paradox between mitotic defects caused by ARID1A inactivation and the lack of genomic instability in ARID1A-mutated cancers.",

keywords = "ARID1A, genomic instability, mitotic defects, OCCC, STAG1, SWI/SNF, telomere",

author = "Timothy Nacarelli and Bo Zhao and Xue Hao and Rugang Zhang",

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year = "2020",

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doi = "10.1080/23723556.2019.1690923",

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AU - Nacarelli, Timothy

AU - Zhao, Bo

AU - Hao, Xue

AU - Zhang, Rugang

PY - 2020/5/3

Y1 - 2020/5/3

N2 - We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1). ARID1A inactivation results in mitotic defects and negatively selects gross chromosomal aberrations, resulting in preservation of genomic stability in ARID1A-mutated cancers. These findings explain the long-standing paradox between mitotic defects caused by ARID1A inactivation and the lack of genomic instability in ARID1A-mutated cancers.

AB - We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1). ARID1A inactivation results in mitotic defects and negatively selects gross chromosomal aberrations, resulting in preservation of genomic stability in ARID1A-mutated cancers. These findings explain the long-standing paradox between mitotic defects caused by ARID1A inactivation and the lack of genomic instability in ARID1A-mutated cancers.

KW - ARID1A

KW - genomic instability

KW - mitotic defects

KW - OCCC

KW - STAG1

KW - SWI/SNF

KW - telomere

UR - https://www.scopus.com/pages/publications/85083761001

UR - https://www.scopus.com/pages/publications/85083761001#tab=citedBy

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DO - 10.1080/23723556.2019.1690923

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JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

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M1 - 1690923

ER -

ARID1A mutation and genomic stability

Abstract

Keywords

ASJC Scopus subject areas

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