Asf1, a Loveseat for a Histone Couple

Yunhe Bao, Xuetong Shen

Research output: Contribution to journalShort survey

3 Scopus citations

Abstract

In this issue of Cell, English et al. (2006) present the first crystal structure of a histone chaperone (Asf1) bound to histones (the H3/H4 heterodimer). The structure provides insights into how histone chaperones participate in nucleosome disassembly. It reveals that Asf1 physically blocks (H3/H4)2 tetramer formation and that the C terminus of H4 undergoes a dramatic conformational change upon binding to Asf1.

Original languageEnglish (US)
Pages (from-to)458-460
Number of pages3
JournalCell
Volume127
Issue number3
DOIs
StatePublished - Nov 3 2006

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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