Abstract
Background and Objectives: Perioperative red blood cell transfusions (PBT) may be associated with worse survival. In this study of adults undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), we investigated whether there was an association between PBT and survival. Materials and Methods: A retrospective study of adults who had undergone CRS-HIPEC for appendiceal carcinomatosis was conducted. Univariate and multivariate analyses were used to identify factors associated with survival. Results: Of the 270 patients analysed, 170 (63%) received PBT. A PBT was not significantly associated with recurrence-free survival (RFS) (HR = 1·03; 95% CI: 0·7–1·51; P = 0·879) or overall survival (OS) (HR = 0·65; 95% CI: 0·38–1·11; P = 0·116). Higher number of PBT units (≥5) was not associated with worse RFS (P = 0·077) or OS (P = 0·079). Independent predictors of poor survival included as follows: estimated blood loss and high tumour grade for RFS (both P < 0·001), and male gender (P = 0·029) and high tumour grade (P < 0·001) for OS. Higher preoperative haemoglobin was independently associated with better RFS (P = 0·011) and OS (P = 0·006). Conclusions: In this retrospective study of adults who had undergone CRS-HIPEC for appendiceal carcinomatosis, PBT was not significantly associated with survival.
Original language | English (US) |
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Pages (from-to) | 567-577 |
Number of pages | 11 |
Journal | Vox Sanguinis |
Volume | 112 |
Issue number | 6 |
DOIs | |
State | Published - Aug 2017 |
Keywords
- adults
- outcomes
- perioperative blood transfusion
ASJC Scopus subject areas
- Hematology
MD Anderson CCSG core facilities
- Biostatistics Resource Group