Abstract
Background: Several studies in adult patients have suggested an unfavorable association between opioid consumption and cancer progression. Aims: This study investigated the impact of opioid consumption on the survival of children and adolescents undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. Methods: A retrospective study of patients <19 years who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy was performed. Univariate and multivariate Cox proportional hazard analyses were used to identify factors associated with recurrence-free survival and overall survival. Results: Seventy-five patients were identified. Median age was 11.6 years (range, 1.8–18.9), and 43% was female. Median perioperative opioid consumption was 18.9 morphine dose equivalents per kilogram (range, 0.6–339.6). There was no statistically significant association between opioid consumption and recurrence-free survival [hazard ratio, 1.00; 95% confidence interval, (0.99–1.02), P = 0.55] or overall survival [hazard ratio 1.01; 95% confidence interval (0.99–1.03), P = 0.22]. Independent prognostic factors associated with poor survival included incomplete cytoreduction and extra-abdominal disease. Conclusion: In this retrospective study of children and adolescents who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy, there was no statistically significant association between opioid consumption and recurrence-free survival or overall survival.
Original language | English (US) |
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Pages (from-to) | 648-656 |
Number of pages | 9 |
Journal | Paediatric Anaesthesia |
Volume | 27 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2017 |
Keywords
- adolescent
- child
- complications
- oncology
- opioids
- outcomes
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Anesthesiology and Pain Medicine
MD Anderson CCSG core facilities
- Biostatistics Resource Group