Assessment of a liposomal CT/optical contrast agent for image-guided head and neck surgery

Nidal Muhanna; Donovan Eu; Harley HL Chan; Michael Daly; Inga B. Fricke; Catriona M. Douglas; Jason L. Townson; Jinzi Zheng; Christine Allen; David A. Jaffray; Jonathan C. Irish

doi:10.1016/j.nano.2020.102327

Assessment of a liposomal CT/optical contrast agent for image-guided head and neck surgery

Nidal Muhanna, Donovan Eu, Harley HL Chan, Michael Daly, Inga B. Fricke, Catriona M. Douglas, Jason L. Townson, Jinzi Zheng, Christine Allen, David A. Jaffray, Jonathan C. Irish

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This study evaluates a long-acting liposomal fluorescence / CT dual-modality contrast agent (CF800) in head and neck cancer to enhance intraoperative tumor demarcation with fluorescence imaging and cone-beam computed tomography (CBCT). CF800 was administered to 12 buccal cancer-bearing rabbits. Imaging was acquired at regular time points to quantify time-dependent contrast enhancement. Surgery was performed 5–7 days after, with intraoperative near-infrared fluorescence endoscopy and CBCT, followed by histological and ex-vivo fluorescence assessment. Tumor enhancement on CT was significant at 24, 96 and 120 hours. Volumetric analysis of tumor segmentation showed high correlation between CBCT and micro-CT. Fluorescence signal was apparent in both ex-vivo and in-vivo imaging. Histological correlation showed [100%] specificity for primary tumor. Sensitivity and specificity of CF800 in detecting nodal involvement require further investigation.CF800 is long acting and has dual function for CT and fluorescence contrast, making it an excellent candidate for image-guided surgery.

Original language	English (US)
Article number	102327
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	32
DOIs	https://doi.org/10.1016/j.nano.2020.102327
State	Published - Feb 2021
Externally published	Yes

Keywords

Fluorescence-guided surgery
Head and neck cancer
Image-guided surgery
Nanoparticle
Oral cavity cancer

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Molecular Medicine
Biomedical Engineering
General Materials Science
Pharmaceutical Science

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10.1016/j.nano.2020.102327

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title = "Assessment of a liposomal CT/optical contrast agent for image-guided head and neck surgery",

abstract = "This study evaluates a long-acting liposomal fluorescence / CT dual-modality contrast agent (CF800) in head and neck cancer to enhance intraoperative tumor demarcation with fluorescence imaging and cone-beam computed tomography (CBCT). CF800 was administered to 12 buccal cancer-bearing rabbits. Imaging was acquired at regular time points to quantify time-dependent contrast enhancement. Surgery was performed 5–7 days after, with intraoperative near-infrared fluorescence endoscopy and CBCT, followed by histological and ex-vivo fluorescence assessment. Tumor enhancement on CT was significant at 24, 96 and 120 hours. Volumetric analysis of tumor segmentation showed high correlation between CBCT and micro-CT. Fluorescence signal was apparent in both ex-vivo and in-vivo imaging. Histological correlation showed [100%] specificity for primary tumor. Sensitivity and specificity of CF800 in detecting nodal involvement require further investigation.CF800 is long acting and has dual function for CT and fluorescence contrast, making it an excellent candidate for image-guided surgery.",

keywords = "Fluorescence-guided surgery, Head and neck cancer, Image-guided surgery, Nanoparticle, Oral cavity cancer",

author = "Nidal Muhanna and Donovan Eu and Chan, {Harley HL} and Michael Daly and Fricke, {Inga B.} and Douglas, {Catriona M.} and Townson, {Jason L.} and Jinzi Zheng and Christine Allen and Jaffray, {David A.} and Irish, {Jonathan C.}",

note = "Funding Information: Funding: This work is supported by the Princess Margaret Cancer Foundation (PMCF) – Image Guided Surgery Fund GTx, The Canadian Institutes of Health Research and the National Research Council of Canada Industrial Research Assistance Program (NRC IRAP). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = feb,

doi = "10.1016/j.nano.2020.102327",

language = "English (US)",

volume = "32",

journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",

issn = "1549-9634",

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AU - Muhanna, Nidal

AU - Eu, Donovan

AU - Chan, Harley HL

AU - Daly, Michael

AU - Fricke, Inga B.

AU - Douglas, Catriona M.

AU - Townson, Jason L.

AU - Zheng, Jinzi

AU - Allen, Christine

AU - Jaffray, David A.

AU - Irish, Jonathan C.

N1 - Funding Information: Funding: This work is supported by the Princess Margaret Cancer Foundation (PMCF) – Image Guided Surgery Fund GTx, The Canadian Institutes of Health Research and the National Research Council of Canada Industrial Research Assistance Program (NRC IRAP). Publisher Copyright: © 2020 Elsevier Inc.

PY - 2021/2

Y1 - 2021/2

N2 - This study evaluates a long-acting liposomal fluorescence / CT dual-modality contrast agent (CF800) in head and neck cancer to enhance intraoperative tumor demarcation with fluorescence imaging and cone-beam computed tomography (CBCT). CF800 was administered to 12 buccal cancer-bearing rabbits. Imaging was acquired at regular time points to quantify time-dependent contrast enhancement. Surgery was performed 5–7 days after, with intraoperative near-infrared fluorescence endoscopy and CBCT, followed by histological and ex-vivo fluorescence assessment. Tumor enhancement on CT was significant at 24, 96 and 120 hours. Volumetric analysis of tumor segmentation showed high correlation between CBCT and micro-CT. Fluorescence signal was apparent in both ex-vivo and in-vivo imaging. Histological correlation showed [100%] specificity for primary tumor. Sensitivity and specificity of CF800 in detecting nodal involvement require further investigation.CF800 is long acting and has dual function for CT and fluorescence contrast, making it an excellent candidate for image-guided surgery.

AB - This study evaluates a long-acting liposomal fluorescence / CT dual-modality contrast agent (CF800) in head and neck cancer to enhance intraoperative tumor demarcation with fluorescence imaging and cone-beam computed tomography (CBCT). CF800 was administered to 12 buccal cancer-bearing rabbits. Imaging was acquired at regular time points to quantify time-dependent contrast enhancement. Surgery was performed 5–7 days after, with intraoperative near-infrared fluorescence endoscopy and CBCT, followed by histological and ex-vivo fluorescence assessment. Tumor enhancement on CT was significant at 24, 96 and 120 hours. Volumetric analysis of tumor segmentation showed high correlation between CBCT and micro-CT. Fluorescence signal was apparent in both ex-vivo and in-vivo imaging. Histological correlation showed [100%] specificity for primary tumor. Sensitivity and specificity of CF800 in detecting nodal involvement require further investigation.CF800 is long acting and has dual function for CT and fluorescence contrast, making it an excellent candidate for image-guided surgery.

KW - Fluorescence-guided surgery

KW - Head and neck cancer

KW - Image-guided surgery

KW - Nanoparticle

KW - Oral cavity cancer

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ER -

Assessment of a liposomal CT/optical contrast agent for image-guided head and neck surgery

Abstract

Keywords

ASJC Scopus subject areas

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