@inproceedings{15f6fbdca1e54461afdd50478ab0c2e6,
title = "Assessment of human colorectal cancer using co-registered photoacoustic and ultrasound tomography system",
abstract = "Colorectal cancer is the second most common malignancy diagnosed globally and the 4th leading cause of cancer mortality. Critical gaps exist in diagnostic and surveillance imaging modalities for colorectal neoplasia. We have conducted a pilot study using a real-time co-registered photoacoustic (PAT) and ultrasound (US) tomography system. A total of 23 ex vivo human colorectal tissue samples (19 colon and 4 rectum) were imaged immediately after surgical resection. These results indicate potential of using PAT/US for future cancer screening and post-treatment surveillance of colon and rectum. The image resolution of the current system is low (∼ 250 μm axial resolution) due to the commercial endo-cavity ultrasound transducer array (6 MHz central frequency, 80% bandwidth). To solve the problem of image resolution, we decoded the pin configuration of a high-frequency transducer array (15 MHz central frequency, 9-18 MHz bandwidth) and adapted it to our home-made 128 channels ultrasound pulsing and receiving system to perform high-frequency PAT/US imaging. We achieved a lateral resolution of ∼ 150 μm and axial resolution of ∼ 120 μm. We also imaged a post-treated human rectum sample to evaluate the system performance.",
keywords = "Ex-vivo and in-vivo study, High-frequency photoacoustic imaging system, Human colorectal cancer, Photoacoustic and ultrasound imaging, Quantitative analysis",
author = "Guang Yang and Eghbal Amidi and William Chapman and Hongbo Luo and Kexin Huang and Sreyankar Nandy and Atahar Mostafa and {Shihab Uddin}, {K. M.} and Shuang Zhou and Heba Abdelal and Zahra Alipour and Deyali Chatterjee and Matthew Mutch and Quing Zhu",
note = "Funding Information: Acknowledgments: Research in this publication was partially funded by R01CA151570, R01CA237664, and R01EB002136, and supported by the Washington University School of Medicine Surgical Oncology Basic Science and Translational Research Training Program grant T32CA009621 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Guang Yang acknowledges the support of Imaging Science Pathway Trainee Fellowship from Washington University. We gratefully acknowledge the support of Michelle Sperry for consenting patients and Hai Li for valuable discussions. Funding Information: Research in this publication was partially funded by R01CA151570, R01CA237664, and R01EB002136, and supported by the Washington University School of Medicine Surgical Oncology Basic Science and Translational Research Training Program grant T32CA009621 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Guang Yang acknowledges the support of Imaging Science Pathway Trainee Fellowship from Washington University. We gratefully acknowledge the support of Michelle Sperry for consenting patients and Hai Li for valuable discussions. Publisher Copyright: {\textcopyright} 2020 SPIE.; Photons Plus Ultrasound: Imaging and Sensing 2020 ; Conference date: 02-02-2020 Through 05-02-2020",
year = "2020",
doi = "10.1117/12.2544424",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Oraevsky, {Alexander A.} and Wang, {Lihong V.}",
booktitle = "Photons Plus Ultrasound",
}