@inbook{e1351339d586405aadf29e1fe4532551,
title = "Assessment of In vivo siRNA delivery in cancer mouse models",
abstract = "RNA interference (RNAi) has rapidly become a powerful tool for target discovery and therapeutics. Small interfering RNAs (siRNAs) are highly effective in mediating sequence-specific gene silencing. However, the major obstacle for using siRNAs as cancer therapeutics is their systemic delivery from the administration site to target cells in vivo. This chapter describes approaches to deliver siRNA effectively for cancer treatment and discusses in detail the current methods to assess pharmacokinetics and biodistribution of siRNAs in vivo.",
keywords = "Cancer therapy, Delivery, Ovarian cancer, Stem-loop RT-PCR, siRNA",
author = "Hiroto Hatakeyama and Sherry Wu and Mangala, {Lingegowda S.} and Gabriel Lopez-Berestein and Sood, {Anil K.}",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2016.",
year = "2016",
month = jan,
day = "1",
doi = "10.1007/978-1-4939-3378-5_15",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "189--197",
booktitle = "Methods in Molecular Biology",
}