@inbook{8c4ef4ead0c849cb91f6fc63563e5135,
title = "Assessment of In Vivo siRNA Delivery in Cancer Mouse Models",
abstract = "RNA interference (RNAi) has rapidly become a powerful tool for target discovery and therapeutics. Small interfering RNAs (siRNAs) are highly effective in mediating sequence-specific gene silencing. However, the major obstacle for using siRNAs for cancer therapeutics is their systemic delivery from the administration site to target cells in vivo. This chapter describes approaches to deliver siRNA effectively for cancer treatment and discusses in detail the current methods to assess pharmacokinetics and biodistribution of siRNAs in vivo.",
keywords = "Cancer Therapy, Chitosan-siRNA Nanoparticles, Ovarian Cancer, Stem-loop RT-PCR, siRNA Delivery",
author = "Mangala, {Lingegowda S.} and Cristian Rodriguez-Aguayo and Emine Bayraktar and Jennings, {Nicholas B.} and Gabriel Lopez-Berestein and Sood, {Anil K.}",
note = "Funding Information: L.S.M was supported by CPRIT (DP 150091 and RP120214). C. R-A. was supported by the NIH through the Ovarian SPORE Career Enhancement Program and NCI grant P50 CA217685. Portions of this work were supported by NIH grants (P50CA217685, P50CA098258, CA016672, CA209904, UO1 CA213759), the American Cancer Society Research Professor Award, and the Frank McGraw Memorial Chair in Cancer Research. This research was also supported, in part, by the Blanton-Davis Ovarian Cancer Research Program. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2021",
doi = "10.1007/978-1-0716-1697-0_14",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "157--168",
booktitle = "Methods in Molecular Biology",
}