Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer: An Analysis of Data from the I-SPY2 Randomized Clinical Trial

W. Fraser Symmans, Christina Yau, Yunn Yi Chen, Ron Balassanian, Molly E. Klein, Lajos Pusztai, Rita Nanda, Barbara A. Parker, Brian Datnow, Gregor Krings, Shi Wei, Michael D. Feldman, Xiuzhen Duan, Beiyun Chen, Husain Sattar, Laila Khazai, Jay C. Zeck, Sharon Sams, Paulette Mhawech-Fauceglia, Mara RendiSunati Sahoo, Idris Tolgay Ocal, Fang Fan, Lauren Grasso Lebeau, Tuyethoa Vinh, Megan L. Troxell, A. Jo Chien, Anne M. Wallace, Andres Forero-Torres, Erin Ellis, Kathy S. Albain, Rashmi K. Murthy, Judy C. Boughey, Minetta C. Liu, Barbara B. Haley, Anthony D. Elias, Amy S. Clark, Kathleen Kemmer, Claudine Isaacs, Julie E. Lang, Hyo S. Han, Kirsten Edmiston, Rebecca K. Viscusi, Donald W. Northfelt, Qamar J. Khan, Brian Leyland-Jones, Sara J. Venters, Sonal Shad, Jeffrey B. Matthews, Smita M. Asare, Meredith Buxton, Adam L. Asare, Hope S. Rugo, Richard B. Schwab, Teresa Helsten, Nola M. Hylton, Laura Van 'T Veer, Jane Perlmutter, Angela M. Demichele, Douglas Yee, Donald A. Berry, Laura J. Esserman

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Importance: Residual cancer burden (RCB) distributions may improve the interpretation of efficacy in neoadjuvant breast cancer trials. Objective: To compare RCB distributions between randomized control and investigational treatments within subtypes of breast cancer and explore the relationship with survival. Design, Setting, and Participants: The I-SPY2 is a multicenter, platform adaptive, randomized clinical trial in the US that compares, by subtype, investigational agents in combination with chemotherapy vs chemotherapy alone in adult women with stage 2/3 breast cancer at high risk of early recurrence. Investigational treatments graduated in a prespecified subtype if there was 85% or greater predicted probability of higher rate of pathologic complete response (pCR) in a confirmatory, 300-patient, 1:1 randomized, neoadjuvant trial in that subtype. Evaluation of a secondary end point was reported from the 10 investigational agents tested in the I-SPY2 trial from March 200 through 2016, and analyzed as of September 9, 2020. The analysis plan included modeling of RCB within subtypes defined by hormone receptor (HR) and ERBB2 status and compared control treatments with investigational treatments that graduated and those that did not graduate. Interventions: Neoadjuvant paclitaxel plus/minus 1 of several investigational agents for 12 weeks, then 12 weeks of cyclophosphamide/doxorubicin chemotherapy followed by surgery. Main Outcomes and Measures: Residual cancer burden (pathological measure of residual disease) and event-free survival (EFS). Results: A total of 938 women (mean [SD] age, 49 [11] years; 66 [7%] Asian, 103 [11%] Black, and 750 [80%] White individuals) from the first 10 investigational agents were included, with a median follow-up of 52 months (IQR, 29 months). Event-free survival worsened significantly per unit of RCB in every subtype of breast cancer (HR-positive/ERBB2-negative: hazard ratio [HZR], 1.75; 95% CI, 1.45-2.16; HR-positive/ERBB2-positive: HZR, 1.55; 95% CI, 1.18-2.05; HR-negative/ERBB2-positive: HZR, 2.39; 95% CI, 1.64-3.49; HR-negative/ERBB2-negative: HZR, 1.99; 95% CI, 1.71-2.31). Prognostic information from RCB was similar from treatments that graduated (HZR, 2.00; 95% CI, 1.57-2.55; 254 [27%]), did not graduate (HZR, 1.87; 95% CI, 1.61-2.17; 486 [52%]), or were control (HZR, 1.79; 95% CI, 1.42-2.26; 198 [21%]). Investigational treatments significantly lowered RCB in HR-negative/ERBB2-negative (graduated and nongraduated treatments) and ERBB2-positive subtypes (graduated treatments), with improved EFS (HZR, 0.61; 95% CI, 0.41-0.93) in the exploratory analysis. Conclusions and Relevance: In this randomized clinical trial, the prognostic significance of RCB was consistent regardless of subtype and treatment. Effective neoadjuvant treatments shifted the distribution of RCB in addition to increasing pCR rate and appeared to improve EFS. Using a standardized quantitative method to measure response advances the interpretation of efficacy. Trial Registration: ClinicalTrials.gov Identifier: NCT01042379.

Original languageEnglish (US)
Pages (from-to)1654-1663
Number of pages10
JournalJAMA Oncology
Volume7
Issue number11
DOIs
StatePublished - Nov 2021

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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