Assessment of Vascular Remodeling Under Antiangiogenic Therapy Using DCE-MRI and Vessel Size Imaging

Stefan Zwick, Ralph Strecker, Valerji Kiselev, Peter Gall, Jochen Huppert, Moritz Palmowski, Wiltrud Lederle, Eva C. Woenne, Arne Hengerer, Matthias Taupitz, Wolfhard Semmler, Fabian Kiessling

Research output: Contribution to journalArticle

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Abstract

Purpose: To assess vascular remodeling in tumors during two different antiangiogenic therapies with dynamic con- trast-enhanced magnetic resonance imaging (DCE-MRI) and vessel size imaging and to evaluate the vessel size index (VSI) as a novel biomarker of therapy response. Materials and Methods: In two independent experiments, nude mice bearing human skin squamous cell carcinoma xenografts were treated with a vascular endothelial growth factor (VEGF) inhibitor (bevacizumab) or a multitargeted tyrosine kinase inhibitor (SU11248). Changes in tumor vascularity were assessed by DCE-MRI and vessel size im- aging. DCE-MRI data were analyzed applying a two-com- partment model (Brix), calculating the parameters Ampli- tude and kep. Results: For both experiments Amplitude decreased signif- icantly in treated tumors while k ep did not change signifi- cantly. VSI showed controversial results. VSI was signifi- cantly increased in SU11248-treated A431 tumors, whereas no changes were found in bevacizumab-treated HaCaT-ras-A-5RT3 tumors. Immunohistology confirmed these results and suggest differences in the maturation of tumor vascularization as a possible explanation. Conclusion: DCE-MRI and vessel size imaging provide re- liable and supplementing biomarkers of antiangiogenic therapy response. The results of both methods are in ex- cellent agreement with histology. Nevertheless, our results also indicate that vascular remodeling is complex and that a uniform response cannot be expected for different tumors and therapies.

Original languageEnglish (US)
Pages (from-to)1125-1133
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume29
Issue number5
DOIs
StatePublished - May 1 2009

Fingerprint

Magnetic Resonance Imaging
Neoplasms
Therapeutics
Biomarkers
Vascular Remodeling
Heterografts
Nude Mice
Protein-Tyrosine Kinases
Vascular Endothelial Growth Factor A
Squamous Cell Carcinoma
Histology
Skin
sunitinib
Bevacizumab

Keywords

  • Antiangiogenic therapy
  • DCE-MRI
  • Magnetic resonance imaging
  • Therapy monitoring
  • Tumor
  • Vessel size imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Zwick, S., Strecker, R., Kiselev, V., Gall, P., Huppert, J., Palmowski, M., ... Kiessling, F. (2009). Assessment of Vascular Remodeling Under Antiangiogenic Therapy Using DCE-MRI and Vessel Size Imaging. Journal of Magnetic Resonance Imaging, 29(5), 1125-1133. https://doi.org/10.1002/jmri.21710

Assessment of Vascular Remodeling Under Antiangiogenic Therapy Using DCE-MRI and Vessel Size Imaging. / Zwick, Stefan; Strecker, Ralph; Kiselev, Valerji; Gall, Peter; Huppert, Jochen; Palmowski, Moritz; Lederle, Wiltrud; Woenne, Eva C.; Hengerer, Arne; Taupitz, Matthias; Semmler, Wolfhard; Kiessling, Fabian.

In: Journal of Magnetic Resonance Imaging, Vol. 29, No. 5, 01.05.2009, p. 1125-1133.

Research output: Contribution to journalArticle

Zwick, S, Strecker, R, Kiselev, V, Gall, P, Huppert, J, Palmowski, M, Lederle, W, Woenne, EC, Hengerer, A, Taupitz, M, Semmler, W & Kiessling, F 2009, 'Assessment of Vascular Remodeling Under Antiangiogenic Therapy Using DCE-MRI and Vessel Size Imaging', Journal of Magnetic Resonance Imaging, vol. 29, no. 5, pp. 1125-1133. https://doi.org/10.1002/jmri.21710
Zwick, Stefan ; Strecker, Ralph ; Kiselev, Valerji ; Gall, Peter ; Huppert, Jochen ; Palmowski, Moritz ; Lederle, Wiltrud ; Woenne, Eva C. ; Hengerer, Arne ; Taupitz, Matthias ; Semmler, Wolfhard ; Kiessling, Fabian. / Assessment of Vascular Remodeling Under Antiangiogenic Therapy Using DCE-MRI and Vessel Size Imaging. In: Journal of Magnetic Resonance Imaging. 2009 ; Vol. 29, No. 5. pp. 1125-1133.
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