Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk

Jiangong Niu, Yu Jing Huang, Sheng Wei, Zhensheng Liu, Li E. Wang, Shine Chang, Robert M. Chamberlain, Adel K. El-Naggar, Erich M. Sturgis, Qingyi Wei

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background. To the best of our knowledge, no studies to date have evaluated roles of insulin-like growth factor binding protein 5 (IGFBP5) polymorphisms in risk of squamous cell carcinoma of the head and neck (SCCHN). Methods. A hospital-based study of 1082 patients with SCCHN and 1120 cancer-free controls was performed to investigate associations between 2 functional polymorphisms, -1195T>C and -709G>C, in the IGFBP5 promoter region and SCCHN risk. Results. We demonstrated that the transcription factor, activator protein 1 (AP-1), differentially bound to T or C variants at -1195 in the promoter to regulate the IGFBP5 promoter activity and that the C variant genotypes were associated with deferential risk of late-stage SCCHN, compared to the TT genotype, particularly for human papillomavirus (HPV)-unrelated sites (adjusted odds ratio [OR], 2.21; 95% confidence interval [CI], 1.19-4.11 for CC vs TT). Conclusion. The IGFBP5 -1195T>C polymorphism is functional and may potentially be a biomarker for susceptibility to late-stage SCCHN.

Original languageEnglish (US)
Pages (from-to)650-660
Number of pages11
JournalHead and Neck
Volume33
Issue number5
DOIs
StatePublished - May 2011

Keywords

  • IGFBP5
  • TNM stage
  • association
  • head and neck cancer
  • polymorphism

ASJC Scopus subject areas

  • Otorhinolaryngology

MD Anderson CCSG core facilities

  • Advanced Technology Genomics Core

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