TY - JOUR
T1 - Association between birth weight and diabetes
T2 - Role of body mass index and lifestyle in later life
AU - for the REACTION Study Group
AU - Hu, Chunyan
AU - Mu, Yiming
AU - Wan, Qin
AU - Qin, Yingfen
AU - Hu, Ruying
AU - Shi, Lixin
AU - Su, Qing
AU - Yu, Xuefeng
AU - Yan, Li
AU - Qin, Guijun
AU - Tang, Xulei
AU - Chen, Gang
AU - Gao, Zhengnan
AU - Wang, Guixia
AU - Shen, Feixia
AU - Luo, Zuojie
AU - Chen, Li
AU - Huo, Yanan
AU - Li, Qiang
AU - Ye, Zhen
AU - Zhang, Yinfei
AU - Liu, Chao
AU - Wang, Youmin
AU - Wu, Shengli
AU - Yang, Tao
AU - Deng, Huacong
AU - Chen, Lulu
AU - Zhao, Jiajun
AU - Lu, Jieli
AU - Lin, Lin
AU - Li, Mian
AU - Du, Rui
AU - Xu, Min
AU - Xu, Yu
AU - Wang, Tiange
AU - Zhao, Zhiyun
AU - Chen, Yuhong
AU - Li, Donghui
AU - Bi, Yufang
AU - Wang, Weiqing
AU - Ning, Guang
N1 - Funding Information:
information The research reported herein was supported by the Ministry of Science and Technology of China, Grant/Award Numbers: 2016YFC1305200, 2016YFC1305601, 2016YFC0901201, 2016YFC1305202, 2016YFC1304904; the National Natural Science Foundation of China, Grant/Award Numbers: 81621061, 81561128019, 81670795The authors thank the field workers for their contribution to the study and the participants for their cooperation.
Publisher Copyright:
© 2019 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Background: This study investigated the association between birth weight and diabetes in a Chinese population, and the effects of body mass index (BMI) and lifestyle factors in later life on this association. Methods: Data from 49 118 participants aged ≥40 years with recalled birth weight from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study, a nationwide population-based cohort, were used. Diabetes diagnosis was based on oral glucose tolerance tests and HbA1c measurements. Logistic regression models were used to evaluate the association of birth weight and risk of diabetes in later life. Results: Increased risk of diabetes was associated with lower or higher birth weight. Compared with individuals with a birth weight of 2500 to 3499 g, the odds ratios (ORs) and 95% confidence intervals (CIs) of diabetes for individuals with a birth weight of <2500, between 3500 and 3999, and ≥4000 g were 1.28 (1.11-1.47), 1.11 (1.04-1.19), and 1.20 (1.07-1.34), respectively. Significant associations were prominent in participants with a current BMI ≥24 kg/m2, but not detected in those with a normal BMI (OR 1.20 [95% CI 0.96-1.49], 1.11 [95% CI 0.98-1.25], and 1.10 [95% CI 0.89-1.37], respectively). Moreover, there was no increased risk of diabetes in individuals with a low birth weight but with healthy dietary habits (OR 0.94; 95% CI 0.68-1.29) or ideal physical activity (OR 1.41; 95% CI 0.97-2.04). Conclusions: A U-shaped association was observed between birth weight and the risk of diabetes. Healthy lifestyles (healthy dietary habits or ideal physical activity) may eliminate the negative effects of low birth weight in the development of diabetes, but not the effect of high birth weight.
AB - Background: This study investigated the association between birth weight and diabetes in a Chinese population, and the effects of body mass index (BMI) and lifestyle factors in later life on this association. Methods: Data from 49 118 participants aged ≥40 years with recalled birth weight from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study, a nationwide population-based cohort, were used. Diabetes diagnosis was based on oral glucose tolerance tests and HbA1c measurements. Logistic regression models were used to evaluate the association of birth weight and risk of diabetes in later life. Results: Increased risk of diabetes was associated with lower or higher birth weight. Compared with individuals with a birth weight of 2500 to 3499 g, the odds ratios (ORs) and 95% confidence intervals (CIs) of diabetes for individuals with a birth weight of <2500, between 3500 and 3999, and ≥4000 g were 1.28 (1.11-1.47), 1.11 (1.04-1.19), and 1.20 (1.07-1.34), respectively. Significant associations were prominent in participants with a current BMI ≥24 kg/m2, but not detected in those with a normal BMI (OR 1.20 [95% CI 0.96-1.49], 1.11 [95% CI 0.98-1.25], and 1.10 [95% CI 0.89-1.37], respectively). Moreover, there was no increased risk of diabetes in individuals with a low birth weight but with healthy dietary habits (OR 0.94; 95% CI 0.68-1.29) or ideal physical activity (OR 1.41; 95% CI 0.97-2.04). Conclusions: A U-shaped association was observed between birth weight and the risk of diabetes. Healthy lifestyles (healthy dietary habits or ideal physical activity) may eliminate the negative effects of low birth weight in the development of diabetes, but not the effect of high birth weight.
KW - birth weight
KW - body mass index
KW - diabetes
KW - lifestyle
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U2 - 10.1111/1753-0407.12960
DO - 10.1111/1753-0407.12960
M3 - Article
C2 - 31170331
AN - SCOPUS:85068638621
SN - 1753-0393
VL - 12
SP - 10
EP - 20
JO - Journal of Diabetes
JF - Journal of Diabetes
IS - 1
ER -